UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (date of earliest event reported): May 11, 2012

CYS Investments, Inc.

(Exact name of Registrant as specified in its charter)

890 Winter Street, Suite 200

Waltham, Massachusetts 02451

(Address of principal executive offices) (Zip code)

(617) 639-0440

(Registrant’s telephone number including area code)

Not Applicable

(Former name or former address, if changed from last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

On May 10, 2012, the stockholders of CYS Investments, Inc. (the “Company”) elected the eight nominated directors, including Tanya S. Beder for the first time. In connection with Ms. Beder becoming a director, the Company has entered into an indemnification agreement with Ms. Beder (the “Indemnification Agreement”), the terms and conditions of which are identical to those which the Company has entered into with its other directors. The Indemnification Agreement obligates the Company to indemnify Ms. Beder to the maximum extent permitted by Maryland law and advance to Ms. Beder all related expenses, subject to reimbursement if it is subsequently determined that indemnification is not permitted.

The foregoing description of the Indemnification Agreement is a general description only and is qualified in its entirety by reference to the Indemnification Agreement, the form of which is incorporated herein by reference to the Company’s Registration Statement on Form S-11 (File No. 333-142236).

At the annual meeting of stockholders of the Company held on May 10, 2012, the stockholders (i) elected the eight nominated directors, (ii) approved, on an advisory basis, the compensation of the Company’s named executive officers, (iii) recommended, on an advisory basis, that future advisory votes on named executive officer compensation be conducted every year, and (iv) ratified the appointment of Deloitte & Touche LLP as the Company’s independent registered public accounting firm for the year ending December 31, 2012. As of March 8, 2012, the record date for the annual meeting of stockholders, there were 114,305,993 shares of common stock outstanding and entitled to vote.

The full results of the matters voted on at the annual meeting of stockholders are set forth below:

Proposal 1 — Election of Directors:

Proposal 2 — Advisory Vote on Named Executive Officer Compensation:

Proposal 3 — Advisory Vote on the Frequency of Future Advisory Votes on Named Executive Officer Compensation:

As disclosed above, 47,929,693 of the votes cast on Proposal 3 voted, on an advisory basis, to hold an advisory vote on named executive officer compensation every year. In view of these voting results and in accordance with the Board of Director’s recommendation, the Board of Directors has determined that an advisory vote on named executive officer compensation will be submitted to stockholders every year until the next required advisory vote on the frequency of future advisory votes on named executive officer compensation.

2

Proposal 4 — Ratification of Appointment of Independent Registered Public Accounting Firm:

(d) Exhibits.

3

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this Report to be signed on its behalf by the undersigned hereunto duly authorized.

INDEX TO EXHIBITS