AMENDMENT NO. 1
TO
MANUFACTURING SERVICES AGREEMENT

THIS AMENDMENT NO. 1 TO MANUFACTURING SERVICES AGREEMENT (this “Amendment No. 1”) is made as of March 22, 2015, by and between SciClone Pharmaceuticals International Ltd. (“Customer”); and Lonza Sales Ltd (“Lonza”).

WITNESSETH:

WHEREAS, Customer and Lonza are party to that certain Manufacturing Services Agreement, dated as of April 30, 2014, (the “Agreement”); and

WHEREAS, the parties wish to amend the Agreement as more fully set forth herein;

NOW, THEREFORE, for and in consideration of the premises and the mutual covenants and agreements contained herein and other good and valuable consideration, the receipt, adequacy and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

IN WITNESS WHEREOF, each of the parties hereto has executed, or has caused its duly authorized officer to execute, this Amendment No. 1 as of the date first above written.



Appendix A

PROJECT PLAN SL-001

cGMP Manufacture:

Pursuant to binding Purchase Orders, Lonza will manufacture Batches of Product, in accordance with cGMP, based on the process outlined below:

[***]

Lonza’s obligation to manufacture Batches pursuant to any Purchase Order will be subject to Customer’s obligation to maintain an adequate stock of stationary phase material at Lonza’s facility.  At Customer’s request, Lonza will notify Customer of the quantity and condition of stationary material at Lonza’s facility.  At Customer’s request, and subject to prepayment by Customer of Lonza’s purchase cost and any applicable handling fees charged by Lonza, Lonza will order agreed quantities of stationary material on Customer’s behalf.

Below is a sample production schedule.  Actual production schedule for a binding Purchase Order will depend on Commencement Date and Campaign size.



Project Schedule

[***]





Stability Studies:

Lonza will perform required stability testing of bulk Product on one Batch derived from a cGMP campaign, each year, at Customer’s cost.  Customer must include such testing in a Purchase Order for at least one GMP Batch to be produced during each year.  If included in such Purchase Order, additional real time and accelerated testing may be included according to Customer requirements.  Additional scope and cost may be included based on Customer requirements, as set forth in the Purchase Order, subject to Lonza’s reasonable approval.

When stability testing is to be performed, Lonza shall perform the following activities/objectives:

Pricing

[***]

*Commercial pricing will be adjusted by terms of currency clause below

Currency Clause.  This proposal is based on an exchange rate of:  1 Euro versus [***] USD.  If on the date of invoice the exchange rate has changed more than +/- [***]% then the USD price for the Lonza works and services will be adjusted accordingly to the benefit of either the Customer or Lonza.

Appendix C

SPECIFICATIONS

Bulk Thymalfasin API (Thymosin Alpha 1)

Purity ([***]):  [***]% or greater