Exhibit 5.1

October 20, 2016

SenesTech, Inc.

3140 N. Caden Ct., Suite 1
Flagstaff, AZ 86004

Re: Registration Statement on Form S-1

Ladies and Gentlemen:

We have acted as special counsel to SenesTech, Inc., a Delaware corporation (the “Company”), in connection with the Registration Statement on Form S-1 (File No. 333-213736), as amended (the “Registration Statement”), filed by the Company with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the “Securities Act”). The Registration Statement relates to the offer and sale of up to 2,300,000 shares of the Company’s common stock, par value $0.001 per share (the “Common Stock), which includes up to 2,146,154 shares to be issued and sold by the Company (including 146,154 shares subject to the underwriters’ over-allotment option described in the Registration Statement) (the “Primary Shares”), and up to 153,846 shares to be offered and sold by certain selling stockholders named in the Registration Statement (the “Selling Stockholders”) upon exercise of the underwriters’ over-allotment option described in the Registration Statement (the “Secondary Shares”).

As such special counsel, we have examined originals or copies, certified or otherwise identified to our satisfaction, of such documents, corporate records, certificates of public officials and other instruments as we have deemed necessary for the purposes of rendering this opinion, including, without limitation (a) a form of the Amended and Restated Certificate of Incorporation of the Company; (b) a form of the Amended and Restated Bylaws of the Company; (c) certain resolutions adopted by the board of directors of the Company; and (d) the form of underwriting agreement to be executed by the Company, the Selling Stockholders and the underwriters substantially in the form filed as Exhibit 1.1 to the Registration Statement (the “Underwriting Agreement”). In our examination, we have assumed without verification the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity with the originals of all documents submitted to us as copies, and the legal competence of all signatories to such documents. As to questions of fact material to this opinion, we have relied on certificates or comparable documents of public officials and of officers and representatives of the Company.

We express no opinion herein as to the laws of any state or jurisdiction other than the General Corporation Law of the State of Delaware (including the statutory provisions and all applicable judicial decisions interpreting those laws) and the federal laws of the United States of America.

The aggregate amount of the Secondary Shares equals $2,000,000 divided by the initial public offering price. For purposes of the opinions stated below, we have assumed an initial public offering price of $13.00 (which is the midpoint of the price range set forth on the cover page of the Amendment No. 2 to the Registration Statement) and calculated that the Selling Stockholders may sell up to an aggregate of 153,846 shares in connection with the exercise of the underwriters’ over-allotment option, and the remainder of the 300,000 shares subject to the underwriters’ over-allotment option, or 146,154 shares, may be sold by the Company.

On the basis of the foregoing, and subject to the qualifications, assumptions and limitations stated herein, we are of the opinion that:

We hereby consent to the filing of this opinion letter as Exhibit 5.1 to the Registration Statement and to the use of our name under the caption “Legal Matters” in the Prospectus included in the Registration Statement. In giving this consent, we do not hereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act.