Attached files

file filename
EX-10.64 - EXHIBIT 10.64 - IONIS PHARMACEUTICALS INCex10_64.htm
EX-31.2 - EXHIBIT 31.2 - IONIS PHARMACEUTICALS INCexhibit31_2.htm
EX-21.1 - EXHIBIT 21.1 - IONIS PHARMACEUTICALS INCexhibit21_1.htm
10-K - ISIS PHARMACEUTICALS INC 10-K 12-31-2015 - IONIS PHARMACEUTICALS INCform10k.htm
EX-32 - EXHIBIT 32.1 - IONIS PHARMACEUTICALS INCexhibit32_1.htm
EX-31.1 - EXHIBIT 31.1 - IONIS PHARMACEUTICALS INCexhibit31_1.htm
Exhibit 23.1
 
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the Registration Statements on Form S-3 (Nos. 33-55790, 33-72124, 33-75068, 33-96138  , 333-71911, 333-90811, 333-38844, 333-71116, 333-71176, 333-89066, 333-89626, 333-128156, 333-130639, 333-134380, 333-141447, 333-151076 and 333-188407) and in the related Prospectuses, as applicable, and in the Registration Statements on Form S-8 (Nos. 33-42356, 33-42970, 33-51236, 33-54840, 33-58450, 33-75150, 33-90780  , 333-05825, 333-55683, 333-40336, 333-59296, 333-91572, 333-106859, 333-116962, 333-125911, 333-133853, 333-142777, 333-151996, 333-160269, 333-168674, 333-176136, 333-184788, 333-190408 and 333-207900  ) of Ionis Pharmaceuticals, Inc. of our reports dated February 25, 2016, with respect to the consolidated financial statements of Ionis Pharmaceuticals, Inc. and the effectiveness of internal control over financial reporting of Ionis Pharmaceuticals, Inc. included in this Annual Report (Form 10-K) for the year ended December 31, 2015.
 
 
/s/ ERNST & YOUNG LLP
 
 
San Diego, California
 
February 25, 2016