Exhibit 10.4.1

EIGHTH AMENDMENT TO LEASE

This Eighth Amendment to Lease (hereinafter “Eighth Amendment”) is entered into as of the          day of                          2015 (hereinafter “Effective Date”), by and between PARADIGM RESOURCES, L.C., a Utah limited liability company (hereinafter “Landlord”), and Q THERAPEUTICS, INC., a Delaware corporation (hereinafter “Tenant”).

RECITALS

WHEREAS, Landlord and Tenant entered into that certain Lease dated January 30, 2004 (hereinafter “Lease”), pursuant to which Landlord leased to Tenant that certain premises designated as Suite 102, consisting of approximately 5,357 square feet, situated at 615 Arapeen Drive in Salt Lake City, Utah (hereinafter “Leased Premises”);

WHEREAS, on or about June 3, 2005, Landlord and Tenant entered into a Lease Extension and Modification Agreement;

WHEREAS, on or about April 1, 2006, Landlord received letter notification of Tenant’s desire to exercise its right to extend the Lease;

WHEREAS, on or about April 1, 2007, Landlord and Tenant entered into a Third Lease Extension and Modification Agreement;

WHEREAS, on or about April 1, 2008, Landlord and Tenant entered into a Fourth Lease Extension and Modification Agreement;

WHEREAS, on or about April 1, 2009, Landlord and Tenant entered into a Fifth Lease Extension and Modification Agreement;

WHEREAS, on or about April 1, 2011, Landlord and Tenant entered into a Sixth Lease Extension and Modification Agreement;

WHEREAS, on or about May 9, 2014, Landlord and Tenant entered into a Seventh Lease Extension and Modification Agreement;

WHEREAS, the Rental Term is set to expire of its own terms on March 31, 2015;

WHEREAS, Landlord and Tenant desire to extend the Rental Term for an additional one (1) year period; and

WHEREAS, Landlord and Tenant desire to modify the Lease as follows:

AGREEMENT

NOW, THEREFORE, in consideration and furtherance of the foregoing, the mutual covenants and agreements herein contained and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant agree to the following terms and conditions:

[Signature Pages to Follow]

IN WITNESS THEREOF, the parties hereto have executed this Eighth Amendment as of the date and year first above written.

ACKNOWLEDGMENT OF LANDLORD

On the          day of                          2015, personally appeared O. RANDALL WOODBURY and JEFFREY K. WOODBURY, to me personally known, who being by me duly sworn did say that they are the President and Vice President of WOODBURY CORPORATION, a Utah corporation, which is a Manager of PARADIGM RESOURCES, L.C., the company that executed the within instrument, known to me to be the persons who executed the within instrument on behalf of said company therein named, and acknowledged to me that such company executed the within instrument pursuant to its Operating Agreement.

On the          day of                          2015, personally appeared DON R. BROWN, to me personally known, who being by me duly sworn did say that he is the President of TACHUS, INC., a Utah corporation, which is a Manager of PARADIGM RESOURCES, L.C., the company that executed the within instrument, known to me to be the persons who executed the within instrument on behalf of said company therein named, and acknowledged to me that such company executed the within instrument pursuant to its Operating Agreement.

ACKNOWLEDGMENT OF TENANT

On the          day of                          2015, before me personally appeared STEVEN J. BORST, to me personally known to be the VICE PRESIDENT, FINANCE of Q THERAPEUTICS, INC., a Delaware corporation, the corporation that executed the within instrument, known to me to be the persons who executed the within instrument on behalf of said corporation therein named, and acknowledged to me that such corporation executed the within instrument pursuant to its by-laws or a resolution of its board of directors.