Item 1.01.          Entry into a Material Definitive Agreement.

          On November 14, 2012, MAKO Surgical Corp. (the “Company”) entered into a purchase agreement (the “Purchase Agreement”) with Piper Jaffray & Co. (the “Underwriter”). Pursuant to the Purchase Agreement, the Company agreed to sell and the Underwriter agreed to purchase for resale to the public (the “Public Offering”), subject to the terms and conditions expressed therein, 3,042,000 shares of the Company’s common stock, par value $0.001 per share (the “Common Stock”), at a price per share of $13.15. The Underwriter also had an option to purchase 456,300 additional shares of Common Stock at the same price per share to cover any over-allotments. Delivery of the shares sold is expected to occur on November 19, 2012, subject to customary closing conditions. The foregoing description of the Purchase Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Purchase Agreement, a copy of which is filed herewith as Exhibit 1.1 and is incorporated by reference herein.

          The shares sold were registered pursuant to an effective shelf Registration Statement on Form S-3 (Registration No. 333-181277) (the “Registration Statement”) that the Company filed with the Securities and Exchange Commission under the Securities Act of 1933, as amended, including the prospectus constituting a part thereof, dated May 9, 2012, as supplemented by the final prospectus supplement, dated November 14, 2012 (collectively, the “Prospectus”). In connection with the filing of the Registration Statement and Prospectus, Foley & Lardner LLP, legal counsel to the Company, issued an opinion and consent to the Company as to the validity of the shares of the Common Stock being offered in the Public Offering, which are filed herewith as Exhibits 5.1 and 23.1 and which constitute part of the Registration Statement.

Item 9.01.          Financial Statements and Exhibits.

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