EXHIBIT 99.1

American Science and Engineering, Inc. Reports Results for

Second Quarter Fiscal Year 2013 and Declares a Quarterly Dividend

·                  Backlog up 19% over last quarter

·                  Year-to-date bookings up 21% from same period last year

·                  Book-to-bill this quarter is 1.72

BILLERICA, Mass. — November 5, 2012 — American Science and Engineering, Inc. (NASDAQ: ASEI) (“AS&E”), a leading worldwide supplier of innovative X-ray detection solutions, today reports its financial results for the second quarter of fiscal year 2013 ended September 30, 2012. The Company is reporting revenues of $46,253,000 as compared with revenues of $54,778,000 for the second quarter of fiscal year 2012, net income of $6,399,000 as compared with net income of $6,851,000 for the second quarter of fiscal year 2012, and earnings per share of $0.76 as compared with earnings per share of $0.74 for the second quarter of fiscal year 2012.

For the first six months of fiscal year 2013 ended September 30, 2012, the Company reported revenues of $93,597,000 compared with revenues of $105,881,000 for the same period in the prior fiscal year, net income of $10,601,000 compared with net income of $12,544,000 for the same period in the prior fiscal year, and earnings per share of $1.22 compared with earnings per share of $1.35 for the prior fiscal year.

The Company is reporting $81,662,000 in bookings for the second quarter of fiscal year 2013 as compared with $93,463,000 in bookings for the second quarter of the prior fiscal year. For the first half of fiscal year 2013 the Company reported bookings of $123,296,000 as compared with bookings of $101,804,000 for the same period of the prior fiscal year. Backlog at September 30, 2012 was $222,270,000 as compared with $211,151,000 at September 30, 2011.

“We are pleased with our continued progress this quarter, exhibited by our increase in both sequential bookings and backlog — due in part to steady orders from our cargo and service areas,” commented Anthony Fabiano, AS&E’s President and CEO. “Another highlight of the quarter was the $245 million IDIQ contract from the Transportation Security Administration (TSA) for our SmartCheck® next generation of Advanced Imaging Technology. As part of this contract, AS&E received its first delivery order for three systems to be tested at TSA facilities. AS&E was also awarded U.S. Department of State Small Business Prime Contractor of the Year. We are proud to be the recipient of this award for our significant support of the Merida Initiative in enabling the detection of contraband and other illegal items at the U.S.-Mexico border.”

Continuing with its dividend program started in August 2007, the Company is declaring a quarterly cash dividend of $0.50 per share, payable on December 3, 2012 to the holders of record at the close of business on November 19, 2012.

As previously announced, Anthony Fabiano, AS&E’s President and Chief Executive Officer, and Ken Galaznik, AS&E’s Senior Vice President, Chief Financial Officer and Treasurer, will host the conference call on Monday, November 5, 2012 at 9:30 a.m. ET to discuss the results and respond to questions. To participate in the conference call, please dial 1-877-303-9143 at least 10 minutes prior to its starting time. For international participants, dial 1-760-536-5194. You will be placed on hold until the conference call is ready to begin.  This call is being webcast and can be accessed through the investor relations section at http://ir.as-e.com/eventdetail.cfm?eventid=120623.

An audio replay of the teleconference will be available, in its entirety, starting Monday, November 5, 2012 at 12:00 p.m. ET for a 48-hour period by dialing 1-855-859-2056. Internationally, please dial 1-404-537-3406. The conference identification number is 55329734. The replay will also be available at http://ir.as-e.com/events.cfm.

About AS&E

American Science and Engineering, Inc. (AS&E) is a leading worldwide supplier of innovative X-ray inspection systems. With over 50 years of experience in developing advanced X-ray security systems, the Company’s product line utilizes a combination of technologies, including patented Z Backscatter™ technology, Radioactive Threat Detection (RTD), high energy transmission and dual energy transmission X-ray. These technologies offer superior X-ray threat detection for plastic explosives, plastic weapons, liquid explosives, dirty bombs and nuclear devices. AS&E’s complete range of products include cargo inspection systems for port and border security, baggage screening systems for facility and aviation security, and personnel and passenger screening systems. AS&E® systems protect high-threat facilities and help combat terrorism, trade fraud, drug smuggling, weapon smuggling, illegal immigration, and people smuggling. AS&E customers include leading government agencies, border authorities, military bases, airports and corporations worldwide, including the U.S. Department of Homeland Security (DHS), U.S. Department of Defense (DoD), U.S. Customs and Border Protection (CBP), North Atlantic Treaty Organization (NATO), UK Border Agency (UKBA), Hong Kong Customs, Abu Dhabi Customs, and Saudi Arabia Customs. For more information on AS&E products and technologies, please visit www.as-e.com.

Investor Relations Contact:

Annemarie Sadowski

American Science and Engineering, Inc.

asadowski@as-e.com

1-978-262-8828

Safe Harbor Statement: The foregoing press release contains statements concerning AS&E’s financial performance, markets and business operations that may be considered “forward-looking” under applicable securities laws.  AS&E wishes to caution readers of this press release that actual results might differ materially from those projected in any forward-looking statements. Factors which might cause actual results to differ materially from those projected in the forward-looking statements contained herein include the following: significant reductions, delays or cancellations (in full or in part) in procurements of the Company’s systems by the United States and other governments; disruption in the supply of any source component incorporated into AS&E’s products; litigation seeking to restrict the use of intellectual property used by the Company; limitations under certain laws on the Company’s ability to protect its own intellectual property; potential product liability claims against the Company; global political trends and events which affect public perception of the threat presented by drugs, explosives and other contraband; global economic developments and the ability of governments and private organizations to fund purchases of the Company’s products to address such threats; the potential insufficiency of Company resources, including human resources, capital, plant and equipment and management systems, to accommodate any future growth; technical problems and other delays that could impact new product development and the Company’s ability to adapt to changes in technology and customer requirements; competitive pressures; lengthy sales cycles both in United States government procurement and procurement abroad;  future delays in federal funding, the market price of the company’s stock prevailing from time to time, the nature of other investment opportunities presented to the company from time to time,  the company’s cash flows from operations and market and general economic conditions. These and certain other factors which might cause actual results to differ materially from those projected are detailed from time to time in AS&E’s periodic reports and registration statements filed with the Securities and Exchange Commission, which important factors are incorporated herein by reference. AS&E undertakes no obligation to update forward looking statements to reflect changed assumptions, the occurrence of unanticipated events, or changes in future operating results, financial condition or business over time. Readers are further advised to review the “Risk Factors” set forth in the Company’s most recent Form 10-Q and Form 10-K,  which further detail and supplement the factors described in this Safe Harbor Statement.  Among other disclosures, the Risk Factors disclose risks pertaining to that portion of the Company’s business that is dependent on United States government contracting as well as international customers.

AMERICAN SCIENCE AND ENGINEERING, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(in thousands, except per share amounts)

(unaudited)

The results of operations reported herein may not be indicative of future financial conditions or results of future operations.

AMERICAN SCIENCE AND ENGINEERING, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(in thousands)

(unaudited)

AMERICAN SCIENCE AND ENGINEERING, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(in thousands)

(unaudited)

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