UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 8-K

Current Report

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): May 24, 2012

NUVASIVE, INC.

(Exact name of registrant as specified in its charter)

7475 Lusk Boulevard, San Diego, California 92121

(Address of principal executive offices, with zip code)

(858) 909-1800

(Registrant’s telephone number, including area code)

n/a

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions ( see General Instruction A.2. below):

Item 5.07 Submission of Matters to a Vote of Security Holders.

On May 24, 2012, NuVasive, Inc. (the “Company”), held its Annual Meeting of Stockholders (the “Annual Meeting”). As of March 28, 2012, the record date of the Annual Meeting, there were 42,993,018 outstanding shares of the Company’s common stock. At the Annual Meeting, a quorum of 39,090,654 shares of the Company’s common stock were represented in person or by proxy. The Company’s stockholders elected three Class II directors and approved two of the three proposals listed below. The proposals are described in detail in the Company’s definitive proxy statement for the Annual Meeting that was filed with the Securities and Exchange Commission (“SEC”) on April 9, 2012. The final votes on the proposals presented at the Annual Meeting are as follows:

Proposal 1:

Each of Peter C. Farrell, Ph.D., AM, Lesley H. Howe and Eileen M. More was elected as a Class II director to hold office until the 2015 Annual Meeting of Stockholders and until his or her successor is elected and has qualified, or if sooner, until the director’s death, resignation or removal, by the following vote:

Each of Alexis V. Lukianov, Jack R. Blair, Robert J. Hunt, Peter M. Leddy, Ph.D. and Richard W. Treharne, Ph.D. continue to serve as directors of the Company after the Annual Meeting.

Proposal 2:

Approval by the Company’s stockholders by advisory (non-binding) vote on the compensation of the Company’s named executive officers, as disclosed in the Company’s proxy statement for the Annual Meeting pursuant to the compensation disclosure rules of the SEC, failed by the following vote:

Proposal 3:

Ratification of the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2012 was approved by the following vote:

Proposal 4:

Approval by the Company’s stockholders, solely to preserve the Company’s ability to receive corporate income tax deductions that may become available pursuant to Internal Revenue Code Section 162(m), (“Section 162(m)”), (i) of the material terms of the Company’s 2004 Equity Incentive Plan (the “2004 Plan”) and (ii) of an amendment to the 2004 Plan to expand upon the objectively determinable performance criteria that may be utilized with respect to performance awards intended to qualify as performance-based compensation under Section 162(m) was approved by the following vote:

No other items were presented for stockholder approval at the Annual Meeting.

Item 7.01 Regulation FD Disclosure.

Company Statement Regarding Advisory Vote on Executive Compensation

The Company, its Board of Directors and its Compensation Committee acknowledge that a majority of the Company’s stockholders have voted on an advisory (non-binding) basis against the compensation of the Company’s named executive officers. The Company is determined to create lasting value for its stockholders and has engaged with many stockholders to ensure alignment of executive compensation with performance over the long term.

The following are some of the steps taken over the past year, in support of the Company’s initiative to improve the link between executive pay and Company performance:

The Company will continue to explore ways to further enhance its performance-based compensation programs.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.