Delaware

(State or other jurisdiction of
incorporation

or organization)

2836

(Primary Standard Industrial

Classification Code Number)

27-1285782

(I.R.S. Employer Identification No.)

10399 West 70th Street

Eden Prairie, MN 55344

(952) 942-6000

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Jeff Ross

Chief Executive Officer

Miromatrix Medical Inc.

10399 West 70^th Street

Eden Prairie, MN 55344

(952) 942-6000

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies of all communications, including communications sent to agent for service, should be sent to:

Steven Kennedy

Jonathan Zimmerman

Faegre Drinker Biddle & Reath LLP

2200 Wells Fargo Center

90 S. Seventh Street

Minneapolis, Minnesota 55402

(612) 776-7000

Ryan Brauer

Joseph Schauer

Fredrikson & Byron, P.A.

200 S. Sixth Street

Suite 400

Minneapolis, MN 55402

(612) 492-7000

Approximate date of commencement of proposed sale to the public: As soon as practicable after this
registration statement is declared effective.

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, as amended (“Securities Act”), check the following box: ¨

If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ¨

Large accelerated filer ¨

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨

Title of Each Class of

Securities to be Registered

Amount to be

Registered(1)

Proposed Maximum

Offering
Price Per Share

Proposed Maximum

Aggregate

Offering
Price

Amount of

Registration Fee(2)

(2)

Calculated pursuant to Rule 457(a) under the Securities Act of 1933, as amended, or the Securities Act, for the purpose of determining the registration fee. The registrant previously registered securities with an proposed maximum aggregate offering price not to exceed $41,400,000 on a Registration Statement on Form S-1, as amended (File No. 333-256649), which was declared effective by the Securities and Exchange Commission on June 23, 2021. In accordance with Rule 462(b) under the Securities Act, an additional amount of securities having a proposed maximum aggregate offering price of 8,280,000 are hereby registered, which includes the additional shares that the underwriters have the option to purchase.

Exhibit

No.