Exhibit 99.1

From:                                      @fda.hhs.gov>

Sent: Friday, November 6, 2020 2:23 PM

To:                         @praxismedicines.com>

Subject: IND 145451

Hello             ,

This email is in reference to your IND 145451 dated October 8, 2020 for PRAX-114.

This email serves to inform you that we have reviewed your submission and your study has been placed on a full clinical hold.

All Hold and Non-hold comments will be communicated to you in next 30 days via formal correspondence.

Thanks,

Division of Psychiatry

Center for Drug Evaluation & Research

U.S. Food and Drug Administration

Confidentiality Notice: This Electronic message, together with its attachments, if any, is intended to be viewed only by the individual to whom it is addressed. It may contain information that is privileged, confidential, protected information and/or exempt from disclosure under applicable law. Any dissemination, distribution or copying of this communication is strictly prohibited without prior permission. If the reader of this message is not the intended recipient or if you have received this communication in error, please send notification immediately by return e-mail and delete the original message and any copies of it from your computer system.