Exhibit 99.1

				NEWS RELEASE

Achaogen Reports First Quarter 2018 Financial Results and Provides Corporate Update

— FDA Advisory Committee voted in favor of plazomicin for treatment of adults with complicated urinary tract infections —

— Conference call today at 8:30 a.m. Eastern Time —

SOUTH SAN FRANCISCO, Calif., May 4, 2018 – Achaogen, Inc. (NASDAQ: AKAO), a late-stage biopharmaceutical company discovering and developing innovative antibacterials addressing multi-drug resistant (MDR) gram-negative infections, today reported financial results for the first quarter ended March 31, 2018, and provided an update on its corporate and clinical development activities.

“With a unanimous vote earlier this week in favor of plazomicin for the treatment of patients with complicated urinary tract infections (cUTI), we are laser-focused on the potential launch of our first drug,” said Blake Wise, Achaogen’s Chief Executive Officer. “We remain committed to our vision of developing new treatment options for patients with serious bacterial infections.”

Recent Highlights and Upcoming Milestones

Other Corporate Milestones

				NEWS RELEASE

First Quarter 2018 Financial Results

Cash Position: At March 31, 2018, Achaogen had $144.0 million in unrestricted cash, cash equivalents and short-term investments compared to $164.8 million at December 31, 2017. In February, Achaogen refinanced a $25.0 million secured debt line it had with Solar Capital with a new $50.0 million secured debt line with Silicon Valley Bank, and has drawn $25.0 million under the Silicon Valley Bank agreement to repay the Solar Capital facility. As previously disclosed, the Company issued 2,144,454 shares of common stock under its at-the-market equity facility for net proceeds, in the first quarter, of $24.0 million.

Revenue: Contract revenue totaled $2.1 million for the first quarter of 2018 compared to $7.5 million for the same period of 2017. The decrease in contract revenue during the first quarter was primarily due to lower Biomedical Advanced Research and Development Authority (BARDA) contract revenues. As of March 31, 2018, $9.6 million remains under the BARDA C-Scape contract and up to an additional $6.0 million may be available under BARDA contract options. All Achaogen revenue consists of U.S. government and Gates Foundation funding for the research and development of product candidates.

Research and Development (R&D): R&D expenses in the first quarter of 2018 were $30.9 million, compared to $18.6 million reported for the same period in 2017. The increase in R&D expenses during the quarter was primarily due to increases in headcount, facility expenses, external expenses related to plazomicin product supply, C-Scape and early research program expenses.

General and Administrative (G&A): G&A expenses in the first quarter of 2018 were $15.1 million, compared to $6.8 million for the same period in 2017. The increase in G&A expenses during the quarter was primarily due to increases in G&A headcount, facility expenses and expenses related to the potential commercialization of plazomicin.

Change in warrant and derivative liabilities for the first quarter of 2018 was a $2.5 million loss compared to a $15.0 million loss for the same period in 2017. The decrease was primarily due to the change in the estimated fair value of the warrant liability which is mainly driven by the change in our stock price.

Net Loss: Achaogen reported a net loss of $47.2 million for the first quarter of 2018, compared to a net loss of $33.3 million for the same period in 2017. Diluted net loss was $1.06 per share for the first quarter of 2018, compared to diluted net loss of $0.93 per share for the same period of 2017. As of March 31, 2018, there were approximately 44.8 million shares of common stock outstanding.

Conference Call

The Company will host a conference call and webcast today at 8:30 a.m. Eastern Time / 5:30 a.m. Pacific Time. To participate by telephone, please dial 800 239 9838 (Domestic) or 323 794 2551 (International). The conference ID number is 6288003. A live and archived audio webcast can be accessed through the Investors section of the Company’s website at www.achaogen.com. The archived audio webcast will remain available on the Company’s website for 30 days following the conference call.

About Achaogen

Achaogen is a late-stage biopharmaceutical company passionately committed to the discovery, development, and commercialization of innovative antibacterial treatments for MDR gram-negative infections. Achaogen is developing plazomicin, its lead product candidate, for the treatment of serious bacterial infections due to MDR Enterobacteriaceae, including carbapenem-resistant Enterobacteriaceae. The Food and Drug Administration has granted plazomicin Breakthrough Therapy designation for the treatment of bloodstream infections caused by certain Enterobacteriaceae in patients who have limited or no alternative treatment options. Achaogen’s plazomicin program has been funded in part with federal funds from the Biomedical Advanced Research and Development Authority (BARDA), Office of the Assistant Secretary for Preparedness and Response, Office of the Secretary, Department of Health and Human Services, under Contract No. HHSO100201000046C. The Company’s second product candidate C-Scape, an orally-administered beta-lactam/beta-lactamase inhibitor combination, is funded in part with Federal funds from BARDA, Office of the Assistant Secretary for Preparedness and Response, Office of the Secretary, U.S. Department of Health and Human Services, under Contract No. HHSO100201700021C. Achaogen has other programs in early and late preclinical stages focused on other MDR gram-negative infections and additional disease areas. All product candidates, including plazomicin, are investigational only and have not been approved for commercialization. For more information, please visit www.achaogen.com.

				NEWS RELEASE

Forward-Looking Statements

This press release contains forward-looking statements. All statements other than statements of historical facts contained herein are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to, Achaogen’s expectations regarding potential regulatory approval of plazomicin and other product candidates, Achaogen’s plan to launch plazomicin soon after receiving FDA approval, Achaogen’s plan to submit a MAA to the European Medicines Agency in 2018 and Achaogen’s pipeline of product candidates. Such forward-looking statements involve known and unknown risks, uncertainties and other important factors that may cause Achaogen’s actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the preclinical and clinical development process; the risks and uncertainties of the regulatory approval process; the risks and uncertainties of product sales and effectiveness; Achaogen’s reliance on third-party contract manufacturing organizations for manufacture and supply, including sources of certain raw materials; risk of third-party claims alleging infringement of patents and proprietary rights or seeking to invalidate Achaogen’s patents or proprietary rights; and the risk that Achaogen’s proprietary rights may be insufficient to protect its technologies and product candidates. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Achaogen’s business in general, see Achaogen’s current and future reports filed with the Securities and Exchange Commission, including its Annual Report on Form 10-K filed on February 27, 2018 and its Quarterly Report on Form 10-Q for the quarter ended March 31, 2018 expected to be filed the week of May 7, 2018. Achaogen does not plan to publicly update or revise any forward-looking statements contained in this press release, whether as a result of any new information, future events, changed circumstances or otherwise.

Source: Achaogen, Inc.

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Investor Contact:

Ashley R. Robinson

LifeSci Partners, LLC

arr@lifesciadvisors.com

Media Contact:

Denise T. Powell

Red House Consulting, LLC

dpowell@achaogen.com

				NEWS RELEASE

Achaogen, Inc.

Condensed Consolidated Statements of Operations

(in thousands except share and per share data)

(unaudited)

				NEWS RELEASE

Achaogen, Inc.

Condensed Consolidated Balance Sheets

(in thousands)