UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): November 12, 2015

QUINTILES TRANSNATIONAL HOLDINGS INC.

(Exact name of registrant as specified in its charter)

Registrant’s telephone number, including area code: (919) 998-2000

Not Applicable

(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

On November 12, 2015, Quintiles Transnational Holdings Inc. (the “Company”) entered into a Share Repurchase Agreement (the “Agreement”) with Temasek Life Sciences Private Limited (“Temasek”). Pursuant to the Agreement, on November 13, 2015, the Company will complete the repurchase of 3,000,000 shares of the Company’s common stock, par value $0.01 per share, from Temasek in a private transaction for an aggregate purchase price of approximately $198.7 million. The Company funded this private repurchase transaction with cash on hand. The Agreement was entered into pursuant to the Company’s previously disclosed share repurchase program. Following this repurchase, the Company will have acquired approximately 3.9 million shares since November 2, 2015 in a combination of open market and private transactions and will have approximately $148.6 million remaining under its repurchase authorization.

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.