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EX-99.4 - FACT SHEET, DATED AUGUST 6, 2015 - Emergent BioSolutions Inc.exhibit99_4.pdf
EX-99.5 - FAQ, DATED AUGUST 6, 2015 - Emergent BioSolutions Inc.exhibit99_5.pdf
8-K - Emergent BioSolutions Inc.form8-k_08062015.htm
EX-99.4 - Emergent BioSolutions Inc.exhibit99_4.htm
EX-99.2 - PRESS RELEASE, DATED AUGUST 6, 2015 - Emergent BioSolutions Inc.exhibit99_2.htm
EX-99.3 - PRESENTATION FOR INVESTORS, DATED AUGUST 6, 2015 - Emergent BioSolutions Inc.exhibit99_3.htm
EX-99.5 - Emergent BioSolutions Inc.exhibit99_5.htm
EXHIBIT 99.1

EMERGENT BIOSOLUTIONS REPORTS SECOND QUARTER AND SIX MONTHS 2015 FINANCIAL RESULTS AND REAFFIRMS 2015 GUIDANCE

GAITHERSBURG, MD, August 6, 2015—Emergent BioSolutions Inc. (NYSE: EBS) reported financial results for the quarter and six months ended June 30, 2015.

Financial highlights include:

·
Total revenues: Q2 2015 of $126.1 million, up 14% over prior year; six months 2015 of $189.7 million, up 16% over prior year;
·
GAAP net income/loss: Q2 2015 net income of $14.1 million, or $0.32 per diluted share; six months 2015 net loss of $7.4 million, or $0.19 per diluted share;
·
Adjusted net income/loss: Q2 2015 net income of $17.0 million, or $0.36 per diluted share; six months 2015 net loss of $1.8 million, or $0.05 per diluted share;
·
EBITDA: Q2 2015 of $29.6 million, or $0.62 per diluted share; six months 2015 of $9.6 million, or $0.25 per diluted share; and
·
Adjusted EBITDA: Q2 2015 of $31.0 million, or $0.65 per diluted share; six months 2015 of $12.2 million, or $0.32 per diluted share.

2015 business accomplishments:

·
FDA approval of Anthrasil™
·
Awards to manufacture Ebola monoclonal antibodies under our CIADM arrangement with BARDA
·
Successful dosing of our first patient in the Phase I trial for MOR209/ES414, our immunotherapeutic treatment for prostate cancer
·
FDA approval and launch of IXINITY®, a recombinant factor IX treatment for Hemophilia B
·
Continued steady progress on Building 55 sBLA approval

2015 outlook:

·
Reaffirmation of previous guidance – FY 2015 total revenues of $510-$540 million, net income of $50-$60 million (GAAP) and $60-$70 million (adjusted); and
·
New guidance – Q3 2015 total revenues of $140 to $155 million.


2015 FINANCIAL PERFORMANCE

(I) Quarter Ended June 30, 2015 (unaudited)

Revenues

Product Sales
For Q2 2015, product sales were $82.0 million, an increase of 5% as compared to 2014. The increase primarily reflects increased sales of BioThrax during the quarter.


 
Three Months Ended
June 30,
 
(in millions)
 
2015
   
2014
   
% Change
 
Product Sales
 
BioThrax®
 
$
72.2
   
$
67.5
     
7
%
Other biodefense
   
2.8
     
1.9
     
47
%
Total Biodefense
 
$
75.0
   
$
69.4
     
8
%
                         
Total Biosciences
 
$
7.0
   
$
8.9
     
(21
)%
Total Product Sales
 
$
82.0
   
$
78.3
     
5
%

Contract Manufacturing
For Q2 2015, revenue from our contract manufacturing operations was $8.9 million, a decrease of 3% as compared to 2014. The decrease was primarily due to the timing of fill/finish facility service to third parties.

Contracts, Grants and Collaborations
For Q2 2015, contracts, grants and collaborations revenue was $35.2 million, an increase of 54% as compared to 2014. The increase was primarily due to development funding for Anthrasil.

Operating Expenses

Cost of Product Sales and Contract Manufacturing
For Q2 2015, cost of product sales and contract manufacturing was $27.3 million, a decrease of 21% as compared to 2014. The decrease was primarily attributable to the decrease in the BioThrax cost per dose sold associated with increased production yield in the period in which the doses were produced.

Research and Development
For Q2 2015, gross research and development (R&D) expenses were $40.9 million, an increase of 9% as compared to 2014. The increase was primarily attributable to additional R&D expenditures associated with product development programs in the Biodefense segment. Net R&D expenses, which are more representative of the company's actual out-of-pocket investment in product development, are calculated as gross research and development expenses less contracts, grants and collaboration revenues. For Q2 2015, net R&D expenses were $5.7 million, a decrease of 61% as compared to 2014.


 
Three Months Ended
June 30,
 
(in millions)
 
2015
   
2014
   
% Change
 
Research and Development Expenses (Gross)
 
$
40.9
   
$
37.4
     
9
%
Adjustments:
 
Contracts, grants and collaborations revenues
   
35.2
     
22.9
     
54
%
Net Research and Development Expenses
 
$
5.7
   
$
14.5
     
(61
)%

Selling, General and Administrative
For Q2 2015, selling, general and administrative expenses were $36.5 million, an increase of 19% as compared to 2014. The increase was primarily attributable to selling, general and administrative costs associated with the launch of IXINITY and professional services to support the company's strategic growth initiatives.

Net Income
For Q2 2015, GAAP net income per diluted share is computed using the if-converted method. This method requires GAAP net income to be adjusted in the amount of $1.0 million, from $14.1 million to $15.1 million, related to interest expense and amortization of debt issuance cost, both net of tax, associated with the company's 2.875% Convertible Senior Notes due 2021.

(II) Six Months Ended June 30, 2015 (unaudited)

Revenues

Product Sales
For the six months of 2015, product sales were $100.3 million, a decrease of 12% as compared to 2014.  The decrease was primarily attributable to the timing of deliveries of BioThrax to the SNS due to our decision to suspend shipments to the CDC in Q1 2015. Shipments were subsequently resumed in Q2 2015.

 
Six Months Ended
June 30,
 
(in millions)
 
2015
   
2014
   
% Change
 
Product Sales
 
BioThrax®
 
$
72.2
   
$
92.0
     
(22
)%
Other biodefense
   
14.8
     
10.0
     
48
%
Total Biodefense
 
$
87.0
   
$
102.0
     
(15
)%
                         
Total Biosciences
 
$
13.3
   
$
12.0
     
11
%
Total Product Sales
 
$
100.3
   
$
114.0
     
(12
)%
Contract Manufacturing
For six months of 2015, revenue from our contract manufacturing operations was $21.1 million, an increase of 77% as compared to 2014. The increase was primarily due to the impact of fill/finish services revenues for the entire six month period in 2015.

Contracts, Grants and Collaborations
For six months of 2015, contracts, grants and collaborations revenue was $68.3 million, an increase of 78% as compared to 2014. The increase was primarily due to development funding for Anthrasil.

Operating Expenses

Cost of Product Sales and Contract Manufacturing
For the six months of 2015, cost of product sales and contract manufacturing was $46.0 million, a decrease of 14% as compared 2014. The decrease was primarily attributable to a decrease in product sales and contract manufacturing revenues.

Research and Development
For the six months of 2015, gross R&D expenses were $79.6 million, an increase of 18% as compared to 2014. The increase was primarily attributable to additional R&D expenditures in the Biodefense segment.

Net R&D expenses for the six months of 2015 were $11.3 million, a decrease of 62% as compared to 2014.


 
Six Months Ended
June 30,
 
(in millions)
 
2015
   
2014
   
% Change
 
Research and Development Expenses (Gross)
 
$
79.6
   
$
67.7
     
18
%
Adjustments:
 
Contracts, grants and collaboration revenues
   
68.3
     
38.3
     
78
%
Net loss attributable to non-controlling interest
   
--
     
--
     
--
 
Net Research and Development Expenses
 
$
11.3
   
$
29.4
     
(62
)%

Selling, General and Administrative
For the six months of 2015, selling, general and administrative expenses were $70.9 million, an increase of 17% as compared to 2014. The increase was primarily attributable to additional post-acquisition selling, general and administrative costs largely associated with the operations acquired in Q1 2014, including IXINITY launch costs, as well as professional services to support the company's strategic growth initiatives.


(III) Reconciliation of GAAP Net Income to Adjusted Net Income/(Loss), EBITDA and Adjusted EBITDA

This press release contains three financial measures (Adjusted Net Income/(Loss), EBITDA or earnings before interest, taxes, depreciation and amortization, and adjusted EBITDA) that are considered "non-GAAP" financial measures under applicable Securities & Exchange Commission rules and regulations. These non-GAAP financial measures should be considered supplemental to and not a substitute for financial information prepared in accordance with generally accepted accounting principles. The company's definition of these non-GAAP measures may differ from similarly titled measures used by others. Adjusted Net Income adjusts for specified items that can be highly variable or difficult to predict, or reflect the non-cash impact of charges resulting from purchase accounting. EBITDA reflects net income excluding the impact of depreciation, amortization, interest expense and provision for income taxes. Adjusted EBITDA also excludes specified items that can be highly variable and the non-cash impact of certain purchase accounting adjustments. The company views these non-GAAP financial measures as a means to facilitate management's financial and operational decision-making, including evaluation of the company's historical operating results and comparison to competitors' operating results. These non-GAAP financial measures reflect an additional way of viewing aspects of the company's operations that, when viewed with GAAP results and the reconciliations to the corresponding GAAP financial measure, may provide a more complete understanding of factors and trends affecting the company's business.

The determination of the amounts that are excluded from these non-GAAP financial measures are a matter of management judgment and depend upon, among other factors, the nature of the underlying expense or income amounts. Because non-GAAP financial measures exclude the effect of items that will increase or decrease the company's reported results of operations, management strongly encourages investors to review the company's consolidated financial statements and publicly filed reports in their entirety.

The following table provides a reconciliation of GAAP Net Income to Adjusted Net Income for the three month periods as indicated.

 
Three Months Ended
June 30,
(in millions, except per share price)
 
2015
   
2014
 
Source
GAAP Net Income
 
$
14.1
   
$
5.0
 
NA
Adjustments:
Acquisition-related costs
(transaction & integration)
   
1.4
     
2.4
 
SG&A
Non-cash amortization charges
   
2.8
     
2.9
 
COGS, SG&A,
Other Income
Impact of purchase accounting on inventory step-up
   
--
     
1.0
 
COGS
Tax effect
   
(1.3
)
   
(1.9
)
NA
Total Adjustments
   
2.9
     
4.4
 
NA
Adjusted Net Income
 
$
17.0
   
$
9.4
 
NA
Adjusted Net Income Per Diluted Share
 
$
0.36
   
$
0.25
 
NA

The following table provides a reconciliation of GAAP Net Loss to Adjusted Net Loss for the six month periods as indicated.

 
Six Months Ended
June 30,
(in millions, except per share price)
 
2015
   
2014
 
Source
GAAP Net Loss
 
$
(7.4
)
 
$
(15.2
)
NA
Adjustments:
Acquisition-related costs
(transaction & integration)
   
2.5
     
6.3
 
SG&A
Non-cash amortization charges
   
5.3
     
4.5
 
COGS, SG&A,
Other Income
Write-off of syndicated loans
   
--
     
1.8
 
Other Income
Impact of purchase accounting on inventory step-up
   
0.1
     
1.4
 
COGS
Tax effect
   
(2.4
)
   
(4.2
)
NA
Total Adjustments
   
5.6
     
9.8
 
NA
Adjusted Loss
 
$
(1.8
)
 
$
(5.4
)
NA
Adjusted Net Loss Per Diluted Share
 
$
(0.05
)
 
$
(0.15
)
NA

The following table provides a reconciliation of GAAP Net Income to EBITDA and Adjusted EBITDA for the three month periods as indicated.

 
Three Months Ended
June 30,
 
(in millions, except per share price)
 
2015
   
2014
 
GAAP Net Income
 
$
14.1
   
$
5.0
 
Adjustments:
 
+  Depreciation & Amortization
   
8.4
     
8.0
 
+  Provision For Income Taxes
   
5.5
     
2.5
 
-  Total Interest Expense
   
1.6
     
1.7
 
Total Adjustments
   
15.5
     
12.2
 
EBITDA
 
$
29.6
   
$
17.2
 
Additional Adjustments:
               
Acquisition-related costs (transaction & integration)
   
1.4
     
2.4
 
Impact of purchase accounting on inventory step-up
   
--
     
1.0
 
Total Additional Adjustments
   
1.4
     
3.4
 
Adjusted EBITDA
 
$
31.0
   
$
20.6
 

The following table provides a reconciliation of GAAP Net Loss to EBITDA and Adjusted EBITDA for the six month periods as indicated.

 
Six Months Ended
June 30,
 
(in millions, except per share price)
 
2015
   
2014
 
GAAP Net Loss
 
$
(7.4
)
 
$
(15.2
)
Adjustments:
 
+  Depreciation & Amortization
   
16.5
     
14.6
 
+  Benefit From Income Taxes
   
(2.8
)
   
(5.7
)
-  Total Interest Expense
   
3.3
     
5.3
 
Total Adjustments
   
17.0
     
14.2
 
EBITDA
 
$
9.6
   
$
(1.0
)
Additional Adjustments:
               
Acquisition-related costs (transaction & integration)
   
2.5
     
6.3
 
Impact of purchase accounting on inventory step-up
   
0.1
     
1.4
 
Total Additional Adjustments
   
2.6
     
7.7
 
Adjusted EBITDA
 
$
12.2
   
$
6.7
 


CONFERENCE CALL AND WEBCAST INFORMATION

Company management will host a conference call at 8:00 am (Eastern Time) today, August 6, 2015, to discuss these financial results. This conference call can be accessed live by telephone or through Emergent's website.

Live Teleconference Information:
Dial in number: (855) 766-6521
International dial in: (262) 912-6157
Passcode: 78708197
Live Webcast Information:
Visit www.emergentbiosolutions.com
and select the "Investors" section

Pre-registering for the live call will expedite access and minimize hold times. You will be issued a passcode to bypass the operator and connect directly. To pre-register for the call, visit the following website: http://edge.media-server.com/m/p/gprwpcvd/lan/en.

A replay of the call can be accessed on Emergent's website http://www.emergentbiosolutions.com under "Investors."


ABOUT EMERGENT BIOSOLUTIONS INC.

Emergent BioSolutions is a global specialty biopharmaceutical company dedicated to one simple mission—to protect and enhance life. We develop, manufacture, and deliver a portfolio of medical countermeasures for biological and chemical threats as well as emerging infectious diseases. We also develop and commercialize therapeutics and other specialty products for hospitals and clinics in the areas of hematology/oncology, transplantation, infectious diseases and autoimmune disorders. Through our work, we envision protecting and enhancing 50 million lives with our products by 2025. Additional information about the company may be found at www.emergentbiosolutions.com. Follow us @emergentbiosolu.

SAFE HARBOR STATEMENT

This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements, other than statements of historical fact, including our financial guidance, and any other statements containing the words "believes", "expects", "anticipates", "intends", "plans", "forecasts", "estimates" and similar expressions in conjunction with, among other things, discussions of financial performance or financial condition, growth strategy, product sales, manufacturing capabilities, including our current investigation involving our suppliers and contract manufacturers regarding a discovery of foreign particles in two lots of BioThrax, product development, regulatory approvals or expenditures are forward-looking statements. These forward-looking statements are based on our current intentions, beliefs and expectations regarding future events. We cannot guarantee that any forward-looking statement will be accurate. Investors should realize that if underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could differ materially from our expectations. Investors are, therefore, cautioned not to place undue reliance on any forward-looking statement. Any forward-looking statement speaks only as of the date of this press release, and, except as required by law, we do not undertake to update any forward-looking statement to reflect new information, events or circumstances.

There are a number of important factors that could cause the company's actual results to differ materially from those indicated by such forward-looking statements, including the potential outcome of our current investigation of foreign particles discovered in two lots of BioThrax; appropriations for BioThrax procurement; our ability to successfully integrate Cangene Corporation and realize the potential benefits of this acquisition; our ability to obtain new BioThrax sales contracts or modifications to existing contracts; our plans to pursue label expansions and improvements for BioThrax; availability of funding for our US government grants and contracts; our ability to identify and acquire or in-license products or late-stage product candidates that satisfy our selection criteria; whether anticipated synergies and benefits from an acquisition or in-license are realized within expected time periods or at all; our ability to enter into selective collaboration arrangements; the timing of and our ability to achieve milestones in out-license and collaboration contracts; our ability to expand our manufacturing facilities and capabilities; our ability and the ability of our contractors and suppliers to maintain compliance with cGMP and other regulatory obligations; the results of regulatory inspections; our ability to meet operating and financial restrictions placed on us and our subsidiaries that are contained in our senior credit facility; the rate and degree of market acceptance and clinical utility of our products; the success of our ongoing and planned development programs; the timing of and our ability to obtain and maintain regulatory approvals for our product candidates; and our commercialization, marketing and manufacturing capabilities and strategy. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from our expectations in any forward-looking statement. Investors should consider this cautionary statement, as well as the risk factors identified in our periodic reports filed with the SEC, when evaluating our forward-looking statements.

###

Investor Contact
Robert Burrows
Vice President, Investor Relations
(o) 240/631-3280; (m) 240/413-1917
burrowsr@ebsi.com
Media Contact
Tracey Schmitt
Vice President, Global Public Affairs, Corp. Resp.
(o) 240/631-3394
schmittt@ebsi.com

FINANCIAL STATEMENTS FOLLOW


Emergent BioSolutions Inc. and Subsidiaries
 
Consolidated Balance Sheets
 
(in thousands, except share and per share data)
 
         
   
June 30, 2015
   
December 31, 2014
 
ASSETS
 
(Unaudited)
     
Current assets:
       
Cash and cash equivalents
 
$
214,841
   
$
280,499
 
Accounts receivable
   
99,718
     
58,834
 
Inventories
   
84,708
     
65,674
 
Deferred taxes, current portion, net
   
1,483
     
1,710
 
Income tax receivable, net
   
13,142
     
1,357
 
Prepaid expenses and other current assets
   
21,596
     
24,101
 
Total current assets
   
435,488
     
432,175
 
Property, plant and equipment, net
   
320,084
     
313,979
 
In-process research and development
   
52,328
     
60,628
 
Intangible assets, net
   
62,110
     
58,344
 
Goodwill
   
52,585
     
52,585
 
Deferred tax assets, long-term, net
   
13,481
     
12,764
 
Other assets
   
7,247
     
8,216
 
Total assets
 
$
943,323
   
$
938,691
 
LIABILITIES AND STOCKHOLDERS' EQUITY
               
Current liabilities:
               
Accounts payable
 
$
41,824
   
$
40,930
 
Accrued expenses and other current liabilities
   
6,442
     
6,274
 
Accrued compensation
   
26,320
     
31,654
 
Contingent consideration, current portion
   
3,040
     
6,487
 
Provisions for chargebacks
   
1,993
     
2,246
 
Deferred revenue, current portion
   
7,343
     
5,345
 
Total current liabilities
   
86,962
     
92,936
 
Contingent consideration, net of current portion
   
33,795
     
34,599
 
Long-term indebtedness
   
253,000
     
251,000
 
Deferred revenue, net of current portion
   
6,083
     
5,713
 
Other liabilities
   
1,232
     
1,242
 
Total liabilities
   
381,072
     
385,490
 
Commitments and contingencies
               
Stockholders' equity:
               
Preferred stock, $0.001 par value; 15,000,000 shares authorized, 0 shares issued and outstanding at both June 30, 2015 and December 31, 2014
   
-
     
-
 
Common stock, $0.001 par value; 100,000,000 shares authorized, 39,162,799 shares issued and 38,742,610 shares outstanding at June 30, 2015; 38,129,872 shares issued  and 37,709,683 shares outstanding at December 31, 2014
   
39
     
38
 
Treasury stock, at cost, 420,189 common shares at both June 30, 2015 and December 31, 2014
   
(6,320
)
   
(6,320
)
Additional paid-in capital
   
291,339
     
274,222
 
Accumulated other comprehensive loss
   
(3,657
)
   
(3,008
)
Retained earnings
   
280,850
     
288,269
 
Total stockholders' equity
   
562,251
     
553,201
 
Total liabilities and stockholders' equity
 
$
943,323
   
$
938,691
 
                 



Emergent BioSolutions Inc. and Subsidiaries
 
Consolidated Statements of Operations
 
(in thousands, except share and per share data)
 
         
   
Three Months Ended June 30,
 
   
2015
   
2014
 
   
(Unaudited)
 
Revenues:
       
Product sales
 
$
82,023
   
$
78,269
 
Contract manufacturing
   
8,859
     
9,187
 
Contracts, grants and collaborations
   
35,230
     
22,869
 
Total revenues
   
126,112
     
110,325
 
                 
Operating expense:
               
Cost of product sales and contract manufacturing
   
27,266
     
34,507
 
Research and development
   
40,941
     
37,401
 
Selling, general and administrative
   
36,453
     
30,555
 
Income from operations
   
21,452
     
7,862
 
                 
Other income (expense):
               
Interest income
   
273
     
31
 
Interest expense
   
(1,628
)
   
(1,721
)
Other income, net
   
(497
)
   
1,322
 
Total other expense, net
   
(1,852
)
   
(368
)
                 
Income before provision for income taxes
   
19,600
     
7,494
 
Provision for income taxes
   
5,500
     
2,465
 
Net income
 
$
14,100
   
$
5,029
 
                 
Income per share - basic
 
$
0.37
   
$
0.13
 
Income per share – diluted (1)
 
$
0.32
   
$
0.13
 
                 
Weighted-average number of shares - basic
   
38,480,754
     
37,416,554
 
Weighted-average number of shares - diluted
   
47,410,413
     
38,333,425
 



(1)
Due to the if-converted method of accounting for dilutive earnings per share for the three months ended June 30, 2015, the calculation of diluted earnings per share includes adjustments to net income of $809,000 and $219,000, respectively, for interest expense and amortization of debt issuance costs associated with our 2.875% Convertible Senior Notes due 2021.


Emergent BioSolutions Inc. and Subsidiaries
 
Consolidated Statements of Operations
 
(in thousands, except share and per share data)
 
         
   
Six Months Ended June 30,
 
   
2015
   
2014
 
   
(Unaudited)
 
Revenues:
       
Product sales
 
$
100,314
   
$
114,036
 
Contract manufacturing
   
21,102
     
11,913
 
Contracts, grants and collaborations
   
68,329
     
38,260
 
Total revenues
   
189,745
     
164,209
 
                 
Operating expense:
               
Cost of product sales and contract manufacturing
   
46,014
     
53,504
 
Research and development
   
79,643
     
67,657
 
Selling, general and administrative
   
70,946
     
60,644
 
Income from operations
   
(6,858
)
   
(17,596
)
                 
Other income (expense):
               
Interest income
   
355
     
71
 
Interest expense
   
(3,288
)
   
(5,256
)
Other income, net
   
(397
)
   
1,834
 
Total other expense, net
   
(3,330
)
   
(3,351
)
                 
Loss before benefit from income taxes
   
(10,188
)
   
(20,947
)
Benefit from income taxes
   
(2,769
)
   
(5,740
)
Net loss
 
$
(7,419
)
 
$
(15,207
)
                 
Loss per share - basic
 
$
(0.19
)
 
$
(0.41
)
Loss per share - diluted
 
$
(0.19
)
 
$
(0.41
)
                 
Weighted-average number of shares - basic
   
38,216,524
     
37,137,015
 
Weighted-average number of shares - diluted
   
38,216,524
     
37,137,015
 



Emergent BioSolutions Inc. and Subsidiaries
 
Consolidated Statements of Cash Flows
 
(in thousands)
 
         
   
Six Months Ended June 30,
 
   
2015
   
2014
 
Cash flows from operating activities:
 
(Unaudited)
 
         
Net loss
 
$
(7,419
)
 
$
(15,207
)
Adjustments to reconcile to net cash provided by (used in) operating activities:
               
Stock-based compensation expense
   
7,790
     
6,015
 
Depreciation and amortization
   
17,298
     
15,294
 
Incomes taxes
   
630
     
(5,199
)
Change in fair value of contingent consideration
   
751
     
1,630
 
Write off of debt issuance costs
   
-
     
1,831
 
Excess tax benefits from stock-based compensation
   
(7,241
)
   
(5,179
)
Other
   
153
     
499
 
Changes in operating assets and liabilities:
               
Accounts receivable
   
(40,884
)
   
2,274
 
Inventories
   
(19,034
)
   
1,232
 
Income taxes
   
(16,740
)
   
(5,184
)
Prepaid expenses and other assets
   
2,465
     
(567
)
Accounts payable
   
2,062
     
(10,357
)
Accrued expenses and other liabilities
   
157
     
(644
)
Accrued compensation
   
(5,473
)
   
(3,902
)
Provision for chargebacks
   
(253
)
   
284
 
Deferred revenue
   
2,368
     
(1,246
)
Net cash used in operating activities
   
(63,370
)
   
(18,426
)
Cash flows from investing activities:
               
Purchases of property, plant and equipment
   
(19,681
)
   
(9,400
)
Acquisition of Cangene Corporation, net of acquired cash
   
-
     
(178,167
)
Net cash used in investing activities
   
(19,681
)
   
(187,567
)
Cash flows from financing activities:
               
Proceeds from convertible debenture, net of bank fees
   
-
     
241,654
 
Proceeds from long-term debt obligations
   
2,000
     
1,000
 
Issuance of common stock upon exercise of stock options
   
13,162
     
9,969
 
Excess tax benefits from stock-based compensation
   
7,241
     
5,179
 
Principal payments on long-term indebtedness
   
-
     
(62,000
)
Contingent obligation payments
   
(5,002
)
   
(1,019
)
Net cash provided by financing activities
   
17,401
     
194,783
 
                 
Effect of exchange rate changes on cash and cash equivalents
   
(8
)
   
2
 
                 
Net decrease in cash and cash equivalents
   
(65,658
)
   
(11,208
)
Cash and cash equivalents at beginning of period
   
280,499
     
179,338
 
Cash and cash equivalents at end of period
 
$
214,841
   
$
168,130