Exhibit 99.1

SECOND AMENDMENT TO OFFICE SPACE LEASE

THIS SECOND AMENDMENT TO OFFICE SPACE LEASE (this “Second Amendment”) is made as of the 31st day of January, 2013, (“Effective Date”) by and between WASHINGTON STREET ASSOCIATES II, L.P., a Pennsylvania limited partnership (“Landlord”) whose address is 2701 Renaissance Boulevard, 4th Floor, King of Prussia, PA 19406 and NUPATHE, INC., a Delaware corporation whose address is 227 Washington Street, Conshohocken, PA 19428 (“Tenant”).

RECITALS

WHEREAS, Landlord and Tenant entered into that certain Office Space Lease dated January 10, 2008 ( the “Lease”), for approximately 11,075 square feet of rentable area (the “Initial Premises”) on the second floor of that certain building commonly known as Millennium III (the “Building”) located at 227 Washington Street, Conshohocken, Pennsylvania (as more fully described in the Lease); and

WHEREAS, Landlord and Tenant entered into that certain First Amendment to Office Space Lease dated November 1, 2010 (the “Amended Lease”) for an additional approximately two hundred forty (240) square feet of storage space (the “Additional Premises”)  on the ground level of the Building (the “First Amendment,” together with the Lease, hereinafter collectively referred to as the Lease); and

WHEREAS, Tenant and Conshohocken Associates, L.P., whose address is 2701 Renaissance Boulevard, 4th Floor, King of Prussia, PA 19406, entered into that certain License Agreement dated December 1, 2010 for use of approximately four hundred eighty (480) rentable square feet of office space in that certain building known as Millennium I, located at 20 Ash Street, Conshohocken, PA  19428 (the “License Agreement”);

WHEREAS, Tenant desires to extend the term of the Lease on the terms contained in this Second Amendment; and

WHEREAS, Landlord and Tenant desire to amend the Lease as set forth in this Second Amendment.

TERMS

NOW, THEREFORE, for good and valuable consideration, the receipt of which is hereby acknowledged, and intending to be legally bound hereby, the parties hereby agree as follows:

1.                                      Incorporation of Recitals.  The foregoing Recitals are hereby incorporated in and made a part of this Second Amendment by this reference.

2.                                      Certain Definitions.  Except as otherwise defined in this Second Amendment, each capitalized term shall have the meaning ascribed to such term in the Lease.

3.                                      Term.  The Term of the Lease is hereby extended so that it shall end on May 31, 2013, unless sooner terminated as provided in the Lease.

4.                                      Base Rent.  As of the Effective Date, Fixed Basic Rent shall be calculated payable as follows:

5.                                      Confession of Judgment.  Tenant hereby ratifies, confirms and reaffirms in all respects the provisions for confession of judgment for possession contained in Section 28(b)(v) of the Lease as amended by this Second Amendment.

6.                                      Lease in Full Force and Effect; No Conflicts.  The Lease remains in full force and effect and unmodified, except as modified or amended by this Second Amendment.  If there shall be any conflict or inconsistency between the terms and conditions of this Second Amendment and those of the Lease, the terms and conditions of this Second Amendment shall control.

7.                                      Binding Effect.  This Second Amendment shall be binding upon and inure to the benefit of Landlord and Tenant and their respective successors and assigns.

8.                                      Counterparts.  This Second Amendment may be executed and delivered in any number of counterparts, and by facsimile signature or electronic signature, each of which shall be deemed to be an original as against any party whose signature appears thereon, and all of such counterparts shall together constitute one and the same instrument.  This Second Amendment shall become binding when one or more counterparts hereof, individually or taken together, shall bear the signatures of all of the parties reflected hereon as the signatories.

9.                                      Further Assurance Actions.  Each party agrees that it will take all necessary actions requested by the other party to effectuate the purposes of this Second Amendment.

10.                               Entire Agreement.  The Lease, as further amended by this Second Amendment, contains, and is intended as, a complete statement of all of the terms of the arrangements between the parties with respect to the matters pertaining to the Initial Premises and the Additional Premises, supersedes any previous agreements and understandings between the parties with respect to those matters, and cannot be changed or terminated orally.

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11.                               Governing Law.  This Second Amendment shall be governed by and construed in accordance with the substantive laws of the Commonwealth of Pennsylvania.

12.                               Headings.  The Paragraph headings of this Second Amendment are for reference purposes only and are to be given no effect in the construction or interpretation of this Amendment.

13.                               Severability.  Any provision of this Second Amendment that is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions of this Second Amendment or such provision, and any such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction.

14.                               Parties in Interest; No Third-Party Beneficiaries.  Neither the Lease, this Second Amendment nor any other agreement, document or instrument to be delivered pursuant to this Second Amendment shall be deemed to confer upon any person not a party hereto or thereto any rights or remedies hereunder or thereunder.

15.                               Authority.  Landlord and Tenant each represent and warrant to the other party:  (a) the execution, delivery and performance of this Second Amendment have been duly approved by such party and no further corporate action is required on the part of such party to execute, deliver and perform this Second Amendment; (b) the person(s) executing this Second Amendment on behalf of such party have all requisite authority to execute and deliver this Second Amendment; and (c) this Second Amendment, as executed and delivered by such person(s), is valid, legal and binding on such party, and is enforceable against such party in accordance with its terms.

16.                               No Effect on the License Agreement.  Notwithstanding anything set forth herein or in the License Agreement to the contrary, this Second Amendment does not extend the term of, or otherwise modify or amend the License Agreement, which shall expire on March 31, 2013.

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IN WITNESS WHEREOF, the duly authorized officers or representatives of Landlord and Tenant have executed this Amendment under seal as of the day and year first hereinabove written.

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