Exhibit 10.1

CONSULTING AGREEMENT

THIS CONSULTING AGREEMENT (“Agreement”) is made effective as of January __, 2013 (the “Effective Date”) by and between OXiGENE, Inc., a Delaware corporation (“OXiGENE”), with offices at 701 Gateway Blvd., South San Francisco, CA 94080 and David Chaplin, Ph.D. (“CONSULTANT”), having a principal place of business at 14 Plowden Park, Aston Rowant, Watlington, Oxfordshire, OX49 5SX, UK. (OXiGENE and CONSULTANT may be referred to individually as a “Party” or collectively as the “Parties.”)

RECITALS

WHEREAS, OXiGENE desires to retain CONSULTANT to provide consulting services for OXiGENE as indicated in one or more mutually executed exhibits to be attached hereto, as may be amended from time to time; and

WHEREAS, CONSULTANT desires to provide such services to OXiGENE, in accordance with the terms and conditions herein contained.

NOW, THEREFORE, in consideration of the mutual promises herein contained, and for other good and valuable consideration, the receipt and adequacy of which each of the Parties does hereby acknowledge, the Parties, intending to be legally bound, agree as follows:

4.1 OXiGENE agrees to pay CONSULTANT for providing the Services specified in an Exhibit up to a budget cap specified in such Exhibit for Services performed at OXiGENE’s request and invoiced in accordance with this Agreement and such Exhibit. Total charges

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for professional service fees relative to an Exhibit, including reasonable travel and necessary out of pocket expenses incurred by CONSULTANT will not exceed the budget cap specified in such Exhibit. In no event will CONSULTANT perform work requiring expenditures in excess of the budget without prior written approval from OXiGENE. Notwithstanding anything in this Agreement or the Exhibits to the contrary, the aggregate annual compensation payable to CONSULTANT under this Agreement and all Exhibits hereto, exclusive of travel, living and out of pocket expenses incurred by CONSULTANT, shall not exceed the sum of one hundred twenty thousand dollars ($120,000) per calendar year.

4.2 Termination of this Agreement shall not affect OXiGENE’s obligation to pay CONSULTANT for Services satisfactorily performed or reasonable expenses properly incurred prior to the date of termination.

6.1 OXiGENE owns all work prepared or created under this Agreement, including all intellectual property rights in such work (the “OXiGENE Work”). CONSULTANT agrees to maintain and furnish to OXiGENE complete and current records of all inventions or discoveries made under this Agreement, including without limitation the OXiGENE Work and disclose to OXiGENE in writing any such inventions. CONSULTANT agrees to assign to OXiGENE ownership of the OXiGENE Work, including intellectual property rights therein. OXiGENE will bear the expense of such proceedings; provided that, any patent or other legal right so issued to CONSULTANT shall be assigned by CONSULTANT to OXiGENE without charge by CONSULTANT. Upon termination of CONSULTANT’s consulting arrangement with OXiGENE, CONSULTANT shall (i) upon termination of this Agreement or completion of the Services set forth in Exhibit A, all Confidential Information furnished to CONSULTANT shall be returned to OXIGENE promptly at its request, except that CONSULTANT may retain one copy for the sole purpose of ensuring compliance with this Agreement. CONSULTANT shall, at its option, either deliver to OXIGENE all Evaluation Materials or destroy the Evaluation Materials and certify to the OXIGENE that the destruction has been undertaken, except that CONSULTANT may retain one copy for the purpose of ensuring compliance with this Agreement. Notwithstanding the forgoing, CONSULTANT shall not be required to remove or destroy any Confidential Information or Evaluation Materials which is contained on backup media as a result of systematic backups of CONSULTANT’S computer system, provided that CONSULTANT shall not access such backup media for the purpose of recovering the Confidential Information or Evaluation Materials;, and (ii) provide to OXiGENE, in writing, a full, signed statement of all inventions in which it participated prior to termination of the

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consulting arrangement. CONSULTANT further agrees to use best efforts in the course of performing the Services to prevent any violation or infringement of any right, patent, copyright, trademark or right of privacy, or any act that would constitute libel or slander against or violate any other rights of any person, firm or corporation.

6.2 At any time during or after the Term, CONSULTANT agrees that it will fully cooperate with OXiGENE, its attorneys and agents, in the preparation and filing of all papers and other documents as may be required to perfect OXiGENE’s rights in and to any OXiGENE Work, including, but not limited to, joining in any proceeding to obtain letters patent, copyrights, trademarks or other legal rights of the United States and of any and all other countries on such inventions, provided that OXiGENE will bear the expense of such proceedings. CONSULTANT hereby designates OXiGENE as its agent, and grants to OXiGENE a power of attorney with full power of substitution (which power of attorney shall be deemed coupled with an interest), for the purpose of effecting the foregoing assignments from CONSULTANT to OXiGENE.

7.1 The term “Confidential Information” includes all information, whether or not labeled “Confidential”, that (i) is disclosed by OXiGENE to CONSULTANT, or (ii) CONSULTANT is exposed to orally or visually, as a result of being on OXiGENE premises. However, the term “Confidential Information” does not include information that prior, or subsequent to the time of such disclosure, (a) is known to CONSULTANT and is not subject to another confidentiality obligation to OXiGENE, (b) is publicly known at the Effective Date or later becomes publicly known under circumstances involving no breach of this Agreement, (c) is lawfully and in good faith disclosed to CONSULTANT by a third party who is not subject to a confidentiality obligation to OXiGENE, or (d) is independently developed by CONSULTANT as evidenced by its written records.

7.2 CONSULTANT acknowledges that OXiGENE is and will remain the sole owner of Confidential Information. During the term of this Agreement and for a period of five (5) years thereafter, CONSULTANT will take all commercially reasonable precautions to protect the confidentiality of Confidential Information, and will not disclose or use any Confidential Information except with OXiGENE’s knowledge and as necessary to perform the Services. In particular, CONSULTANT may disclose Confidential Information to CONSULTANT Personnel who need to know such Confidential Information in order to provide the Services and who are obligated, in writing, to protect the confidentiality of such Confidential Information under terms no less stringent than those set forth in this Article. If required by law, CONSULTANT may disclose Confidential Information to a governmental authority, provided that reasonable advance notice is given to OXiGENE and CONSULTANT reasonably cooperates with OXiGENE to obtain confidentiality protection of such information.

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10.1 OXiGENE shall indemnify, defend and hold harmless CONSULTANT from and against all claims, actions, suits and proceedings (including reasonable attorney fees) (“Claims”) asserted by any third party based on, arising out of or related to a breach of this Agreement by OXiGENE except to the extent that any such Claims are directly attributable to the willful misfeasance or gross negligence on the part of CONSULTANT.

10.2 If Consultant seeks indemnification under this Article 10, it shall give written notice to OXiGENE of a Claim as soon as reasonably practicable after it receives notice of a Claim and shall reasonably cooperate with OXiGENE in the defense of the Claim. Notwithstanding the foregoing, OXiGENE may not settle any Claim or otherwise agree to an adverse judgment without the express written consent of the Consultant, which consent shall not be unreasonably withheld or delayed.

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All notices provided in accordance with this Article 16, shall be deemed given on the date sent.

Signature Page to Follow

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IN WITNESS WHEREOF, each of the Parties hereto has caused this Agreement to be executed as a sealed instrument by its duly authorized representative as of the date written above.

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Exhibit A

1. Services. CONSULTANT agrees to provide the following consulting services upon OXiGENE’s request:

• Alliance management and technical support of OXiGENE and Baylor University’s ongoing sponsored research programs.

2. Compensation. CONSULTANT will provide to OXiGENE invoices for Services rendered as requested hereunder. As full compensation for Services provided hereunder, OXiGENE will pay to CONSULTANT a flat fee of five thousand US dollars ($5,000) per month for the duration of this Exhibit A. Maximum remuneration for Services performed on a time and materials basis under this Exhibit A, inclusive of travel, living and out of pocket expenses, shall not exceed the amount set forth in OXiGENE Purchase Order Number [            ], as may be amended from time to time by OXiGENE in its sole discretion. The Parties agree that Services performed and travel, living and out of pocket expenses incurred by Consultant beyond such maximum remuneration shall not be subject to payment without the prior written consent of OXiGENE.

3. Invoices. Payment of invoices submitted with the required detail, delineated herein, will be made within thirty (30) days of OXiGENE’s receipt of such invoice. Should any part of the invoice be in dispute, OXiGENE shall pay the remainder of the undisputed amount according to the terms and conditions described herein while said dispute is being resolved.

All invoices must be issued to: “OXiGENE, Inc., Attn: Accounts Payable, 701 Gateway Blvd., South San Francisco, CA 94080” and forwarded via e-mail to ap@oxigene.com for payment.

To avoid any delay in payment, all invoices should clearly contain the detail required by OXiGENE, including:

Consultant’s name & full mailing address

Name the check shall be payable to and the corresponding Tax ID # if applicable

Invoice date

Total amount due & payment currency

Description of services rendered/project and/or study number and/or period ending

Invoices which do not contain the required detail will be rejected and must be resubmitted in order to be processed and paid.

The parties have indicated their acceptance of the terms of this Agreement by the signatures set forth below. Each individual signing on behalf of a corporate entity hereby personally represents and warrants his or her legal authority to legally bind that entity.