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S-1/A - AMENDMENT NO. 5 TO REGISTRATION STATEMENT ON FORM S-1 - OncoMed Pharmaceuticals Incd344523ds1a.htm

Exhibit 23.1

Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” and to the use of our report dated May 11, 2012, in Amendment No. 5 to the Registration Statement (Form S-1 No. 333-181331) and related Prospectus of OncoMed Pharmaceuticals, Inc. for the registration of shares of its common stock.

/s/ Ernst & Young LLP

Redwood City, California

November 30, 2012