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Table of Contents

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

 

FORM 10-Q

 

 

 

x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2012

Or

 

¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from            to            

Commission File Number: 001-35420

 

 

ChemoCentryx, Inc

(Exact Name of Registrant as Specified in Its Charter)

 

 

 

Delaware   94-3254365

(State or Other Jurisdiction of

Incorporation or Organization)

 

(I.R.S. Employer

Identification No.)

850 Maude Avenue

Mountain View, California 94043

(Address of Principal Executive Offices) (Zip Code)

(650) 210-2900

(Registrant’s Telephone Number, Including Area Code)

 

 

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days    Yes  x    No  ¨

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes  x    No  ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

 

Large accelerated filer    ¨    Accelerated filer    ¨
Non-accelerated filer    x  (Do not check if a smaller reporting company)    Smaller reporting company    ¨

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes  ¨    No  x

The number of outstanding shares of the registrant’s common stock, par value $0.001 per share, as of November 8, 2012, was 36,265,320.

 

 

 


Table of Contents

CHEMOCENTRYX, INC.

QUARTERLY REPORT ON FORM 10-Q

For the quarterly period ended September 30, 2012

Table of Contents

 

PART I. FINANCIAL INFORMATION   
Item 1.   

Financial Statements (Unaudited)

     3   
  

Condensed Consolidated Balance Sheets – September 30, 2012 and December 31, 2011

     3   
  

Condensed Consolidated Statements of Operations – Three Months and Nine Months Ended September 30, 2012 and 2011

     4   
  

Condensed Consolidated Statements of Comprehensive Loss – Three Months and Nine Months Ended September 30, 2012 and 2011

     5   
  

Condensed Consolidated Statements of Cash Flows – Nine Months Ended September 30, 2012 and 2011

     6   
  

Notes to Condensed Consolidated Financial Statements

     7   
Item 2.   

Management’s Discussion and Analysis of Financial Condition and Results of Operations

     12   
Item 3.   

Quantitative and Qualitative Disclosures About Market Risk

     18   
Item 4.   

Controls and Procedures

     18   
PART II. OTHER INFORMATION   
Item 1.    Legal Proceedings      19   
Item 1A.    Risk Factors      19   
Item 2.    Unregistered Sales of Equity Securities and Use of Proceeds      19   
Item 3.    Defaults Upon Senior Securities      19   
Item 4.    Mine Safety Disclosures      19   
Item 5.    Other Information      19   
Item 6.    Exhibits      19   
SIGNATURES      19   
EXHIBIT INDEX   

 

2


Table of Contents

PART I. FINANCIAL INFORMATION

 

Item 1. Financial Statements

CHEMOCENTRYX, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(in thousands except share and per share data)

 

     September 30,
2012
    December 31,
2011
 
     Unaudited        
Assets     

Current assets:

    

Cash and cash equivalents

   $ 13,115      $ 40,155   

Short-term investments

     112,357        49,335   

Accounts receivable from related party

     291        507   

Prepaid expenses and other current assets

     750        1,322   
  

 

 

   

 

 

 

Total current assets

     126,513        91,319   

Property and equipment, net

     1,198        1,541   

Long-term investments

     2,773        6,596   

Other assets

     160        2,095   
  

 

 

   

 

 

 

Total assets

   $ 130,644      $ 101,551   
  

 

 

   

 

 

 
Liabilities and Stockholders’ Equity     

Current liabilities:

    

Accounts payable

   $ 574      $ 536   

Accrued liabilities

     6,023        4,692   

Deferred revenue from related party

     4,513        3,628   

Current portion of equipment financing obligations

     517        501   
  

 

 

   

 

 

 

Total current liabilities

     11,627        9,357   

Noncurrent equipment financing obligations

     523        947   

Deferred revenue from related party

     376        4,535   

Convertible note from related party

     —          10,472   

Other non-current liabilities

     113        243   
  

 

 

   

 

 

 

Total liabilities

     12,639        25,554   

Commitments

    

Stockholders’ equity:

    

Preferred stock:

    

Convertible preferred stock $0.001 par value; no shares and 48,989,914 shares authorized and issuable in Series A to E at September 30, 2012 and December 31, 2011, respectively; no shares and 48,664,392 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively; aggregate liquidation preference of $0 and $165,096 at September 30, 2012 and December 31, 2011, respectively;

     —          49   

Preferred stock, $0.001 par value, 10,000,000 shares authorized; no shares issued and outstanding;

     —          —     

Common stock, $0.001 par value, 200,000,000 shares and 68,000,000 shares authorized at September 30, 2012 and December 31, 2011, respectively; 36,204,792 shares and 4,385,439 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively, net of shares subject to repurchase

     36        4   

Additional paid-in capital

     242,326        170,289   

Employee note receivable

     (16     (16 )

Accumulated other comprehensive income (loss)

     51        (31 )

Accumulated deficit

     (124,392     (94,298 )
  

 

 

   

 

 

 

Total stockholders’ equity

     118,005        75,997   
  

 

 

   

 

 

 

Total liabilities and stockholders’ equity

   $ 130,644      $ 101,551   
  

 

 

   

 

 

 

See accompanying notes.

 

3


Table of Contents

CHEMOCENTRYX, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(in thousands, except per share data)

(unaudited)

 

     Three Months Ended
September 30,
    Nine Months Ended
September 30,
 
     2012     2011     2012     2011  

Revenues:

        

Collaborative research and development revenue from related party

   $ 1,128      $ 1,441      $ 3,274      $ 5,621   
  

 

 

   

 

 

   

 

 

   

 

 

 

Operating expenses:

        

Research and development

     8,746        8,321        25,349        22,914   

General and administrative

     2,619        1,772        7,654        5,721   
  

 

 

   

 

 

   

 

 

   

 

 

 

Total operating expenses

     11,365        10,093        33,003        28,635   
  

 

 

   

 

 

   

 

 

   

 

 

 

Loss from operations

     (10,237     (8,652     (29,729     (23,014

Other income (expense):

        

Interest income

     141        95        411        319   

Interest expense

     (20     (117     (776     (170

Other income

     —          16        —          16   
  

 

 

   

 

 

   

 

 

   

 

 

 

Total interest income (expense), net

     121        (6     (365     165   
  

 

 

   

 

 

   

 

 

   

 

 

 

Net loss

   $ (10,116   $ (8,658   $ (30,094   $ (22,849
  

 

 

   

 

 

   

 

 

   

 

 

 

Net loss per share, basic and diluted.

   $ (0.28   $ (2.06   $ (0.86   $ (5.49
  

 

 

   

 

 

   

 

 

   

 

 

 

Shares used in computing basic and diluted loss per share amounts

     36,180        4,201        35,117        4,162   
  

 

 

   

 

 

   

 

 

   

 

 

 

See accompanying notes.

 

4


Table of Contents

CHEMOCENTRYX, INC.

CONDENSED CONSOLIDATED STATEMENT OF COMPREHENSIVE LOSS

(in thousands)

(unaudited)

 

    

Three Months Ended

September 30,

   

Nine Months Ended

September 30,

 
     2012     2011     2012     2011  

Net loss

   $ (10,115   $ (8,658   $ (30,094   $ (22,849

Unrealized gain (loss) on available-for-sale securities

     81        (83     82        (124
  

 

 

   

 

 

   

 

 

   

 

 

 

Comprehensive loss

   $ (10,034   $ (8,741   $ (30,012   $ (22,973
  

 

 

   

 

 

   

 

 

   

 

 

 

 

5


Table of Contents

CHEMOCENTRYX, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(in thousands)

(unaudited)

 

    

Nine Months Ended

September 30,

 
     2012     2011  

Operating activities

    

Net loss

   $ (30,094 )   $ (22,849 )

Adjustments to reconcile net loss to net cash used in operating activities:

    

Depreciation of property and equipment

     456        569   

Stock-based compensation

     3,415        1,970   

Noncash interest expense

     663        101   

Changes in assets and liabilities:

    

Accounts receivable due from related party

     216        11,638   

Prepaids and other current assets

     572        (374

Other assets

     1,935        (636 )

Accounts payable

     38        (446 )

Other liabilities

     1,337        (156 )

Deferred revenue

     (3,274 )     (2,721 )
  

 

 

   

 

 

 

Net cash used in operating activities

     (24,736     (12,904 )

Investing activities

    

Purchases of property and equipment, net

     (113 )     (110 )

Purchase of investments

     (141,977 )     (96,862 )

Maturities of investments

     82,860        93,677   
  

 

 

   

 

 

 

Net cash used in investing activities

     (59,230 )     (3,295 )

Financing activities

    

Proceeds from equipment financing

     —          700   

Payments on equipment financing obligations

     (408 )     (401 )

Proceeds from exercise of stock options

     317        127   

Proceeds from issuance of convertible note

     —          10,000   

Proceeds from exercise of warrants

     —          1,058   

Proceeds from issuance of common stock

     57,017        —     
  

 

 

   

 

 

 

Net cash provided by financing activities

     56,926        11,484   
  

 

 

   

 

 

 

Net decrease in cash and cash equivalents

     (27,040 )     (4,715 )

Cash and cash equivalents at beginning of period

     40,155        12,056   
  

 

 

   

 

 

 

Cash and cash equivalents at end of period

   $ 13,115      $ 7,341   
  

 

 

   

 

 

 

Supplemental disclosures of cash flow information

    

Cash paid for interest

   $ 113      $ 68   

Cash refund for income tax

   $ —        $ (16 )

Non-cash financing activity:

    

Issuance of common stock for settlement of convertible debt, including accrued interest

   $ 10,215      $ —     

See accompanying notes.

 

6


Table of Contents

CHEMOCENTRYX, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

SEPTEMBER 30, 2012

(unaudited)

 

1. Description of Business

ChemoCentryx, Inc. (the Company) commenced operations in 1997. The Company is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing orally administered chemokine-based therapeutics to treat autoimmune diseases, inflammatory disorders and cancer. The Company’s principal operations are in the United States and it operates in one segment.

Unaudited Interim Financial Information

The financial information filed is unaudited. The Condensed Consolidated Financial Statements included in this report reflect all adjustments (consisting only of normal recurring adjustments) that the Company considers necessary for the fair statement of the results of operations for the interim periods covered and of the financial condition of the Company at the date of the interim balance sheet. The December 31, 2011 Condensed Consolidated Balance Sheet was derived from audited financial statements, but does not include all disclosures required by generally accepted accounting principles in the United States of America (GAAP). The results for interim periods are not necessarily indicative of the results for the entire year or any other interim period. The Condensed Consolidated Financial Statements should be read in conjunction with the Company’s financial statements and the notes thereto included in the Company’s annual report on Form 10-K for the year ended December 31, 2011 filed with the Securities and Exchange Commission, or SEC, on March 30, 2012.

Initial Public Offering

In February 2012, the Company completed its initial public offering, or IPO, pursuant to which the Company issued 5,175,000 shares of common stock, including the exercise of the underwriters’ over-allotment option and received (a) net proceeds of $45.0 million, after underwriting discounts, commissions and offering expenses; and (b) gross proceeds of $12.0 million in concurrent private placements of 1,200,000 shares of common stock at the IPO price of $10.00 per share. In addition, in connection with the completion of the Company’s IPO, all convertible preferred stock converted into common stock.

 

2. Summary of Significant Accounting Policies

Use of Estimates

The financial statements are prepared in conformity with GAAP. The Company has made estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates.

Stock Split

In January 2012, the board of directors of the Company approved a one-for-two reverse stock split. All information in this report relating to the number of shares, price per share and per share amounts of common stock gives retroactive effect to the January 2012 one-for-two reverse stock split of the Company’s common stock.

Net Loss Per Share

Basic and diluted net loss per common share is computed by dividing net loss by the weighted-average number of vested common shares outstanding during the period. The convertible preferred stock contained certain participation rights. Participating securities are included in the computation of basic income per share using the two-class method. The calculation of diluted net loss per share excludes potential common stock because its effect is antidilutive. Potential common stock consists of incremental common shares issuable upon the exercise of stock options and warrants, upon the conversion of convertible preferred stock and upon the conversion of the Company’s convertible loans.

 

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Table of Contents

For the nine months ended September 30, 2012 and 2011, the Company’s potential common stock includes the following shares, all of which have been excluded from the computation of diluted net loss per share because their impact is antidilutive:

 

    

Nine Months Ended

September 30,

 
     2012      2011  

Convertible preferred stock

     —           24,332,186   

Options to purchase common stock

     5,396,959         4,172,318   

Warrants to purchase common stock

     309,500         159,500   
  

 

 

    

 

 

 
     5,706,459         28,664,004   
  

 

 

    

 

 

 

 

3. Cash Equivalents and Investments

The amortized cost and fair value of cash and cash equivalents at September 30, 2012 were as follows (unaudited, in thousands):

 

     Amortized      Gross Unrealized     Fair  
     Cost      Gains      Losses     Value  

Money market funds

   $ 18,086       $ 2       $ —        $ 18,088   

Government-sponsored agencies

     6,006         2         (1     6,007   

Commercial paper

     32,132         —           —          32,132   

Corporate debt securities

     71,247         52         (4     71,295   
  

 

 

    

 

 

    

 

 

   

 

 

 

Total available-for-sale securities

   $ 127,471       $ 56       $ (5   $ 127,522   
  

 

 

    

 

 

    

 

 

   

 

 

 

Classified as:

          

Cash equivalents

           $ 12,392   

Short-term investments

             112,357   

Long-term investments

             2,773   
          

 

 

 

Total available-for-sale securities

           $ 127,522   
          

 

 

 

The amortized cost and fair value of cash and cash equivalents at December 31, 2011 were as follows (in thousands):

 

     Amortized      Gross Unrealized     Fair  
     Cost      Gains      Losses     Value  

Money market funds

   $ 41,266       $ —         $ —        $ 41,266   

Government-sponsored agencies

     9,042         2         —          9,044   

Commercial paper

     12,540         1         —          12,541   

Corporate debt securities

     32,528         9         (43 )     32,494   
  

 

 

    

 

 

    

 

 

   

 

 

 

Total available-for-sale securities

   $ 95,376       $ 12       $ (43 )   $ 95,345   
  

 

 

    

 

 

    

 

 

   

 

 

 

Classified as:

          

Cash equivalents

           $ 39,414   

Short-term investments

             49,335   

Long-term investments

             6,596   
          

 

 

 

Total available-for-sale securities

           $ 95,345   
          

 

 

 

All available-for-sale securities held as of September 30, 2012, had contractual maturities of less than two years. There have been no significant realized gains or losses on available-for-sale securities for the periods presented. No available-for-sale securities held as of September 30, 2012, have been in a continuous unrealized loss position for more than 12 months. As of September 30, 2012, unrealized losses on available-for-sale investments are not attributed to credit risk and are considered to be temporary. The Company believes that it is more-likely-than-not that investments in an unrealized loss position will be held until maturity or the recovery of the cost basis of the investment. To date, the Company has not recorded any impairment charges on marketable securities related to other-than-temporary declines in market value.

 

8


Table of Contents
4. Fair Value Measurements

The Company determines the fair value of financial assets and liabilities using three levels of inputs as follows:

Level 1—Inputs which include quoted prices in active markets for identical assets and liabilities.

Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

The Company’s financial assets and liabilities subject to fair value measurements on a recurring basis and the level of inputs used in such measurements are as follows as of September 30, 2012 and December 31, 2011 (in thousands):

 

    

September 30, 2012

(unaudited)

 
Description    Level 1      Level 2      Level 3      Total  

Money market fund

   $ 18,088       $ —         $ —         $ 18,088   

Government-sponsored agencies

     —           6,007         —           6,007   

Commercial paper

     —           32,132         —           32,132   

Corporate debt securities

     —           71,295         —           71,295   
  

 

 

    

 

 

    

 

 

    

 

 

 

Total assets

   $ 18,088       $ 109,434       $ —         $ 127,522   
  

 

 

    

 

 

    

 

 

    

 

 

 

 

     December 31, 2011  
Description    Level 1      Level 2      Level 3      Total  

Money market fund

   $ 41,266       $ —         $ —         $ 41,266   

Government-sponsored agencies

     —           9,044         —           9,044   

Commercial paper

     —           12,541         —           12,541   

Corporate debt securities

     —           32,494         —           32,494   
  

 

 

    

 

 

    

 

 

    

 

 

 

Total assets

   $ 41,266       $ 54,079       $ —         $ 95,345   
  

 

 

    

 

 

    

 

 

    

 

 

 

Convertible debt from related party

   $ —         $ —         $ 10,472       $ 10,472   
  

 

 

    

 

 

    

 

 

    

 

 

 

Total liabilities

   $ —         $ —         $ 10,472       $ 10,472   
  

 

 

    

 

 

    

 

 

    

 

 

 

When the Company uses observable market prices for identical securities that are traded in less active markets, the Company classifies its marketable debt instruments as Level 2. When observable market prices for identical securities are not available, the Company prices its marketable debt instruments using non-binding market consensus prices that are corroborated with observable market data; quoted market prices for similar instruments; or pricing models, such as a discounted cash flow model, with all significant inputs derived from or corroborated with observable market data. Non-binding market consensus prices are based on the proprietary valuation models of pricing providers or brokers. These valuation models incorporate a number of inputs, including non-binding and binding broker quotes; observable market prices for identical or similar securities; and the internal assumptions of pricing providers or brokers that use observable market inputs and, to a lesser degree, unobservable market inputs. The Company corroborates non-binding market consensus prices with observable market data using statistical models when observable market data exists. The discounted cash flow model uses observable market inputs, such as LIBOR-based yield curves, currency spot and forward rates, and credit ratings.

The Company recorded its convertible debt as a liability at fair value, which was estimated at the issuance date using the Probability-Weighted Expected Returns model (PWERM). The PWERM requires inputs such as the expected term of the debt, share price volatility, risk-free interest rate and the likelihood and timing of future equity financing. These assumptions are reviewed each reporting period and changes in the estimated fair value of the convertible note are recognized in interest expense. As of December 31, 2011, the Company estimated the fair value of its convertible debt at approximately $10.5 million. In February 2012, following the completion of the Company’s IPO, all outstanding principal and accrued interest relating to this debt automatically converted into 1,021,490 shares of common stock. The following table shows the change in fair market value of the Company’s liabilities during the nine months ended September 30, 2012 (in thousands):

 

     Fair Market Value  

Convertible debt from related party

  

Balance as of December 31, 2011

   $ 10,472   

Change in fair market value prior to conversion

     794   
  

 

 

 

Balance upon conversion

     11,266   
  

 

 

 

Balance as of September 30, 2012

   $ —     
  

 

 

 

 

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Table of Contents
5. Convertible Preferred Stock

The authorized, issued, and outstanding shares of convertible preferred stock at December 31, 2011 were as follows:

 

Series

   Authorized
Shares
     Shares
Issued and
Outstanding
     Aggregate
Liquidation
Preference
 
                   (in thousands)  

Series A convertible preferred stock

     5,000,000         5,000,000       $ 5,000   

Series B convertible preferred stock

     24,390,790         24,071,790         62,586   

Series C convertible preferred stock

     5,048,469         5,048,469         17,670   

Series D convertible preferred stock

     7,750,655         7,750,655         29,840   

Series E convertible preferred stock

     6,800,000         6,793,478         50,000   
  

 

 

    

 

 

    

 

 

 
     48,989,914         48,664,392       $ 165,096   
  

 

 

    

 

 

    

 

 

 

Conversion

In connection with the completion of the Company’s IPO in February 2012, all convertible preferred stock converted into 24,332,186 shares of common stock.

Warrants to Purchase Convertible Preferred Stock

Series B Convertible Preferred Stock

In February 2012, in connection with the IPO, all outstanding warrants to purchase Series B convertible preferred stock converted into warrants to purchase 159,500 shares of common stock at $5.20 per share, expiring in 2012 through 2014.

 

6. Related-Party Transactions

Glaxo Group Limited

In August 2006, the Company entered into a product development and commercialization agreement with Glaxo Group Limited (GSK). The Company recognized the following revenues from GSK during the three and nine months ended September 30, 2012 and 2011 (in thousands):

 

     Three Months Ended
September 30,
     Nine Months Ended
September 30,
 
     2012      2011      2012      2011  

GSK:

           

Contract revenue

   $ —         $ 534       $ —         $ 2,900   

Recognition of up-front payments

     1,128         907        3,274         2,721   
  

 

 

    

 

 

    

 

 

    

 

 

 

Total revenues

   $ 1,128       $ 1,441       $ 3,274       $ 5,621   
  

 

 

    

 

 

    

 

 

    

 

 

 

In February 2012, based on unblinded data from a Phase I clinical trial of CCX832, the Company and GSK determined not to further advance the development of CCX832 or its two designated back-up compounds. Under the agreement, all rights to CCX832 remain with the Company. At September 30, 2012 and December 31, 2011, the Company had an accounts receivable balance due from GSK of $291,000 and $507,000, respectively.

Techne

In September 2011, the Company entered into a convertible note loan agreement with Techne Corporation, or Techne, one of its principal stockholders, pursuant to which the Company issued a convertible note to Techne with a principal amount of $10.0 million and bearing interest at a rate of 5.0% per annum and a maturity date in September 2021. In February 2012, the Company

 

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completed its IPO, and as such, all outstanding principal and accrued and unpaid interest automatically converted into 1,021,490 shares of common stock at a conversion price equal to the IPO price of $10.00 per share. Upon the conversion of the note in connection with the IPO, Techne received a warrant with a ten-year term to purchase 150,000 shares of the Company’s common stock at an exercise price per share equal to $20.00 per share, or 200% of the IPO price of its common stock. In addition, pursuant to the terms of the convertible note loan agreement, concurrent with the IPO, Techne purchased $5.0 million of the Company’s common stock in a private placement at $10.00 per share.

 

7. Equity Incentive Plans

In May 2002, the stockholders approved the Amended and Restated 1997 Stock Option/Stock Issuance Plan (the 1997 Plan), in September 2002, the stockholders approved the 2002 Equity Incentive Plan (the 2002 Plan, and collectively with the 1997 Plan, the Prior Plans), and in February 2012, the stockholders approved the 2012 Equity Incentive Award Plan (the 2012 Plan, and together with the Prior Plans, the Stock Plans). As of February 8, 2012, the effective date of the 2012 Plan, no further award grants will be made under the Prior Plans.

As of September 30, 2012, the total number of shares available for issuance under the 2012 Plan was 1,577,967, which consists of (a) 3,000,000 shares of the Company’s common stock initially reserved for issuance under the 2012 Plan, (b) 52,576 shares of common stock available for issuance under the Prior Plans as of the effective date of the 2012 Plan and (c) 33,461 shares of common stock subject to outstanding awards under the Stock Plans that were forfeited or lapsed unexercised between the effective date of the 2012 Plan and September 30, 2012, less 1,508,070 shares of common stock granted under the 2012 Plan between February 8, 2012 and September 30, 2012. The number of shares available for issuance under the 2012 Plan will be annually increased by an amount equal to the lesser of: 2,000,000 shares; or, 4% of the outstanding shares of the Company’s common stock as of the last day of the Company’s immediately preceding fiscal year; or, an amount determined by our Board of Directors. As of September 30, 2012, a total of 1,485,070 shares of common stock were subject to outstanding awards under the 2012 Plan.

Under the 2012 Plan, incentive stock options may be granted by the Board of Directors to employees, and nonstatutory options may be granted by the Board of Directors to employees, officers, directors and consultants, at exercise prices of not less than 100% of the fair value at the date of grant. Under the 2012 Plan, options may be granted with different vesting terms from time to time, but not to exceed 10 years from the date of grant. Outstanding options generally vest over four years, with 25% of the total grant vesting on the first anniversary of the option grant date and 1/36th of the remaining grant vesting each month thereafter.

In February 2012, the stockholders approved the 2012 Employee Stock Purchase Plan, (the ESPP), which plan became effective as of February 8, 2012. A total of 300,000 shares of the Company’s common stock have been reserved for issuance under the ESPP. In addition, the number of shares available for issuance under the ESPP will be annually increased on the first day of each fiscal year during the term of the ESPP, beginning with the 2013 fiscal year, by an amount equal to the lesser of: 300,000 shares; 1% of outstanding shares of the Company’s common stock; or, an amount determined by its Board of Directors. The ESPP provides for an aggregate limit of 3,300,000 shares of common stock that may be issued under the ESPP during the term of the ESPP. As of September 30, 2012, no shares of common stock have been issued to employees under the ESPP.

As of September 30, 2012, the Company had the following option activity under its Stock Plans:

 

     Shares     Weighted Average
Exercise Price
     Weighted Average
Remaining
Contractual Term
     Aggregate
Intrinsic
Value
 

Options outstanding at December 31, 2011

     4,016,393      $ 4.89         

Granted

     1,508,070        13.47         

Exercised

     (89,977     3.51         

Forfeited

     (37,527     9.32         
  

 

 

         

Options outstanding at September 30, 2012

     5,396,959      $ 7.28         6.87 years       $ 26,685,432   
  

 

 

         

Stock-based Compensation

As of September 30, 2012, $13.7 million of total unrecognized compensation expense related to employee stock options was expected to be recognized over a weighted-average period of 2.88 years. The fair values of the employee stock options granted under the Company’s Stock Plans were estimated at the date of grant using the Black-Scholes option-pricing model. Since implementing the ESPP in 2012, the Company has recorded approximately $101,000 in stock compensation expense relating to the ESPP.

 

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

The following discussion and analysis should be read in conjunction with our financial statements and accompanying notes included in this Quarterly Report on Form 10-Q and the financial statements and accompanying notes thereto and Management’s Discussion and Analysis of Financial Condition and Results of Operations included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2011, filed with the Securities and Exchange Commission, or SEC, on March 30, 2012.

Forward-Looking Statements

This Quarterly Report on Form 10-Q contains forward-looking statements that involve risks and uncertainties. All statements other than statements of historical facts contained in this Quarterly Report on Form 10-Q are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “may,” “could,” “will,” “would,” “should,” “expect,” “plan,” “anticipate,” “believe,” “estimate,” “intend,” “predict,” “seek,” “contemplate,” “potential” or “continue” or the negative of these terms or other comparable terminology. These forward-looking statements include, but are not limited to, statements about:

 

   

the initiation, timing, progress and results of our preclinical studies and clinical trials, and our research and development programs;

 

   

our ability to advance drug candidates into, and successfully complete, clinical trials;

 

   

our collaborator’s exercise of its license option;

 

   

the commercialization of our drug candidates;

 

   

the implementation of our business model, strategic plans for our business, drug candidates and technology;

 

   

the scope of protection we are able to establish and maintain for intellectual property rights covering our drug candidates and technology;

 

   

estimates of our expenses, future revenues, capital requirements and our needs for additional financing;

 

   

the timing or likelihood of regulatory filings and approvals;

 

   

our ability to maintain and establish collaborations or obtain additional government grant funding;

 

   

our financial performance; and

 

   

developments relating to our competitors and our industry.

These statements relate to future events or to our future financial performance and involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by these forward-looking statements. Factors that may cause actual results to differ materially from current expectations include, among other things, those included in “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2011, filed with the SEC on March 30, 2012 and in our Quarterly Report on Form 10-Q for the three month period ended March 31, 2012, filed with the SEC on May 10, 2012.

Any forward-looking statement in this Quarterly Report on Form 10-Q reflects our current views with respect to future events and is subject to these and other risks, uncertainties and assumptions relating to our operations, results of operations, industry and future growth. Given these uncertainties, you should not place undue reliance on these forward-looking statements. For all forward-looking statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Except as required by law, we assume no obligation to update or revise these forward-looking statements for any reason, even if new information becomes available in the future.

ChemoCentryx®, the ChemoCentryx logo, Traficet™ and Traficet-EN™ are our trademarks in the United States, the European Community, Australia and Japan. EnabaLink® and RAM® are our trademarks in the United States. Each of the other trademarks, trade names or service marks appearing in this Quarterly Report on Form 10-Q belongs to its respective holder.

Unless the context requires otherwise, in this Quarterly Report on Form 10-Q the terms “ChemoCentryx,” “we,” “us” and “our” refer to ChemoCentryx, Inc., a Delaware corporation, and our subsidiary taken as a whole.

 

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Overview

ChemoCentryx is a biopharmaceutical company focused on discovering, developing and commercializing orally-administered therapeutics to treat autoimmune diseases, inflammatory disorders and cancer. We currently have four drug candidates in clinical development, and expect to advance at least one additional drug candidate into clinical development in 2012. Our drug candidates include:

 

   

Traficet-EN (CCX282, GSK1605786 or recent USAN accepted name - vercirnon), a CCR9 inhibitor and our most advanced drug candidate, currently in four pivotal Phase III clinical trials being conducted by our partner Glaxo Group Limited, or GSK, an affiliate of GlaxoSmithKline, for the treatment of patients with moderate-to-severe Crohn’s disease;

 

   

CCX140, a CCR2 inhibitor and our lead independent drug candidate, which successfully completed a Phase II clinical trial in type 2 diabetics and is currently in two Phase II clinical trials in patients with diabetic nephropathy, a form of kidney disease;

 

   

CCX354 (GSK2941266), which successfully completed a Phase II proof-of-concept clinical trial for the treatment of rheumatoid arthritis, or RA and was subsequently exclusively licensed to GSK, now solely responsible for further clinical development;

 

   

CCX168, currently in a Phase II proof-of-concept clinical trial for the treatment of anti-neutrophil cytoplasmic antibody, or ANCA, associated vasculitis;

 

   

CCX872, our independent next generation CCR2 inhibitor for the treatment of metabolic diseases, currently expected to enter a Phase I clinical trial by the end of 2012;

 

   

CCX507, our independent next generation CCR9 inhibitor for the treatment of inflammatory bowel disease, currently expected to enter a Phase I clinical trial by the end of 2012 or first quarter 2013; and

 

   

CCX662/CCX650, our independent drug candidates for the treatment of glioblastoma multiforme, or GBM, and other cancers.

CCX140, CCX872, CCX507 and CCX662 are wholly owned and are being developed independently by us, while Traficet-EN, CCX354 and CCX168 are subject to our collaboration agreement with GSK. In December 2009 and November 2011, GSK exercised its options to obtain exclusive licenses for the further development and commercialization of Traficet-EN and CCX354, respectively. Upon exercise of these options, GSK assumed sole responsibility for the further development and commercialization of these drug candidates and each of their two respective back-up compounds. We are also advancing several additional independent drug candidates through preclinical development. In addition, our strategy has been to identify next generation compounds related to our drug candidates. All of our drug candidates, including those under our collaboration agreement with GSK, have been internally discovered.

In August 2006, we entered into our strategic alliance with GSK. We have received over $250 million from GSK, of which approximately $82 million was in the form of equity investments, and the balance from up-front and milestone payments, research funding and option exercise fees. Under the terms of our agreement with GSK, we are responsible for the discovery and development of small molecule antagonists targeting four defined chemokine and chemo-attractant receptor targets (CCR9, CCR1, C5aR and ChemR23) and for advancing them through clinical proof-of-concept. If we demonstrate successful clinical proof-of-concept, GSK is entitled to options to exclusively license drug candidates that are subject to the collaboration and two defined back-up compounds for each drug candidate for further development and commercialization on a worldwide basis. Upon exercising any of its options to drug candidates under the collaboration, GSK is solely responsible for all further clinical development and commercialization expenditures worldwide with respect to that drug candidate and its two designated back-up compounds. In exchange for the rights granted to GSK upon the exercise of its options, we are also entitled to receive regulatory and commercial milestone payments, as earned under the terms of our agreement, and royalties on the net sales of licensed drugs. The agreement contemplated up to six drug options, each of which covers a drug candidate against the four defined targets, including Traficet-EN (CCR9), CCX354 (CCR1), CCX168 (C5aR) and CCX832 (ChemR23), and their associated back-up compounds. The other two drug options were for second generation drug candidates and their associated back-up compounds. However, we and GSK chose not to nominate second generation drug candidates against any of the four defined targets during the agreement’s research term, which has expired. In addition, based on unblinded data from a recently completed Phase I clinical trial of CCX832, in February 2012, we and GSK determined not to further advance the development of CCX832 or its two designated back-up compounds. CCX832 was our drug candidate that we intended to develop for certain skin inflammatory diseases. GSK has already exercised its options to Traficet-EN and CCX354 and each of their two respective defined back-up compounds. Thus, GSK’s only remaining option is to CCX168 and its associated back-up compounds. If GSK does not exercise its option to CCX168, we will evaluate our alternatives for further development of this drug candidate, which may entail internally developing it or identifying other collaboration partners for its development.

Since commencing our operations in 1997, our efforts have focused on research, development and the advancement of our drug candidates into and through clinical trials. As a result, we have incurred significant losses. We have funded our operations primarily

 

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through the sale of convertible preferred and common stock, contract revenue under our collaborations, government contracts and grants and borrowings under equipment financing arrangements. In February 2012, we completed our initial public offering, or IPO, pursuant to which we received net proceeds of $45.0 million, after underwriting discounts, commissions and offering expenses. We also received gross proceeds of $12.0 million from concurrent private placements of common stock at the IPO price of $10.00 per share. In addition, the outstanding principal amount of $10.0 million and accrued interest under a convertible note we had issued to Techne Corporation, or Techne, one of our principal stockholders, automatically converted into shares of our common stock in connection with our IPO at a conversion price equal to the IPO price. As of September 30, 2012, we had an accumulated deficit of $124.4 million. We expect to continue to incur net losses as we develop our drug candidates, expand clinical trials for our drug candidates currently in clinical development, expand our research and development activities, expand our systems and facilities, seek regulatory approvals and engage in commercialization preparation activities in anticipation of Food and Drug Administration, or FDA, approval of our drug candidates. In addition, if a product is approved for commercialization, we will need to expand our organization. Significant capital is required to launch a product and many expenses are incurred before revenues are received. We are unable to predict the extent of any future losses or when we will become profitable, if at all.

Critical Accounting Policies and Significant Judgments and Estimates

There have been no material changes in our critical accounting policies during the nine months ended September 30, 2012, as compared to those disclosed in “Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations—Critical Accounting Policies and Significant Judgments and Estimates” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2011, filed with the SEC on March 30, 2012.

JOBS Act

In April 2012, the JOBS Act was enacted. Section 107 of the JOBS Act provides that an emerging growth company can utilize the extended transition period provided in Section 7(a)(2)(B) of the Securities Act for implementing new or revised accounting standards. In other words, an emerging growth company can delay the adoption of certain accounting standards until those standards would otherwise apply to private companies. We have elected to delay such adoption of new or revised accounting standards, and as a result, we may not implement new or revised accounting standards on the relevant dates on which adoption of such standards is required for other companies.

Subject to certain conditions set forth in the JOBS Act, as an emerging growth company, we intend to rely on certain of these exemptions, including without limitation, providing an auditor’s attestation report on our system of internal controls over financial reporting pursuant to Section 404 and implementing any requirement that may be adopted regarding mandatory audit firm rotation or a supplement to the auditor’s report providing additional information about the audit and the financial statements (auditor discussion and analysis). These exemptions will apply for a period of five years following the completion of our initial public offering although if the market value of our common stock that is held by nonaffiliates exceeds $700 million as of any June 30th before that time, we would cease to be an emerging growth company as of the following December 31st.

Results of Operations

Revenue

We have not generated any revenue from product sales. For the three and nine months ended September 30, 2012, our revenue was derived from the recognition of up-front payments received from GSK. Total revenues for the period, as compared to the same period in the prior year, were as follows (in thousands):

 

     Three Months Ended
September 30,
     Nine Months Ended
September 30,
 
     2012     2011      2012     2011  

GSK:

         

Contract revenue

   $ —        $ 534       $ —        $ 2,900   

Recognition of up-front payments

     1,128        907        3,274        2,721  
  

 

 

   

 

 

    

 

 

   

 

 

 

Total revenues

   $ 1,128      $ 1,441       $ 3,274      $ 5,621   
  

 

 

   

 

 

    

 

 

   

 

 

 

Dollar decrease

   $ (313      $ (2,347  

Percentage decrease

     (22 )%         (42 )%   

 

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The decreases in revenue from 2011 to 2012 for both the three and nine month periods were primarily due to lower funding of clinical support from GSK for CCX354 and CCX168 partially offset by a slight increase in revenue relating to the upfront payment from GSK following our decision not to advance CCX832, thereby shortening the term of our performance obligation.

Research and development expenses

Research and development expenses represent costs incurred to conduct research into the discovery and development of our understanding of the chemokine system; the discovery and development of novel small molecule therapeutics, such as Traficet-EN and CCX140; the development of our suite of proprietary drug discovery technologies, known collectively as EnabaLink, which includes our proprietary Reverse Activation of Migration, or RAM, screening technology and preclinical studies and clinical trials of our drug candidates. We expense all research and development expenses as they are incurred. These expenses consist primarily of salaries and related benefits, including stock-based compensation, third-party contract costs relating to research, formulation, manufacturing, preclinical study and clinical trial activities, laboratory consumables, and allocated facility costs. Total research and development expenses for the period, as compared to the same period in the prior year, were as follows (in thousands):

 

     Three Months Ended
September 30,
     Nine Months Ended
September 30,
 
     2012     2011      2012     2011  

Research and development expenses

   $ 8,746      $ 8,321       $ 25,349      $ 22,914   

Dollar increase

   $ 425         $ 2,435     

Percentage increase

     5        11  

The increases in expense from 2011 to 2012 for both the three and nine month periods were primarily due to an increase in expenses relating to patient enrollment in our Phase II trials of CCX140 in diabetic nephropathy and an increase in expenses associated with advancing our independent next-generation drug candidates into the clinic. These increases were partially offset by a decrease in expense associated with the completion of our Phase II clinical trial of CCX354 in rheumatoid arthritis in 2011 and the subsequent transfer of CCX354 to GSK following GSK’s exercise of its option to CCX354 in November 2011. In addition, CCX168 associated expenses were lower in 2012, as 2011 included the recognition of Phase II study start-up expenses which were not recurring in 2012. We track specific project expenses that are directly attributable to our clinical development candidates and preclinical candidates that have been nominated and selected for further development. Such project specific expenses include third-party contract costs relating to formulation, manufacturing, preclinical studies and clinical trial activities. Unlike our early stage research and drug discovery programs, we allocate research and development salaries, benefits or indirect costs to our development candidates and we have included such costs in the project specific expenses. All remaining research and development expenses are reflected in “Other” which represents early stage drug discovery programs. Such expenses include allocated employee salaries and related benefits, stock-based compensation, consulting and contracted services to supplement our in-house laboratory activities, laboratory consumables and allocated facility costs associated with these earlier stage programs.

At any given time, we typically have several active early stage research and drug discovery projects. Our internal resources, employees and infrastructure are not directly tied to any individual research or drug discovery project and are typically deployed across multiple projects. As such, we do not maintain information regarding these costs incurred for our early stage research and drug discovery programs on a project specific basis. The following table summarizes our research and development expenses by project (in thousands):

 

     Three Months Ended
September 30,
     Nine Months Ended
September 30,
 
     2012      2011      2012      2011  

Development Candidate (Target)

           

CCX140 (CCR2)

   $ 3,503       $ 3,294       $ 9,837       $ 6,271   

CCX872 (CCR2)

     673         —           2,528         —     

CCX507 (CCR9)

     475         —           2,722         —     

CCX662 (CXCR7)

     387         216         2,591         795   

CCX168 (C5aR)

     1,210         1,055         1,993         3,304   

CCX354 (CCR1)

     —           703         109         3,430   

CCX832 (ChemR23)(1)

     13         435         158         1,507   

Other (CCR2 3G, CCR6, CCR4, CXCR6, other)

     2,485         2,618         5,411         7,607   
  

 

 

    

 

 

    

 

 

    

 

 

 

Total research and development

   $ 8,746       $ 8,321       $ 25,349       $ 22,914   

 

(1) In February 2012, we and GSK determined not to further advance the development of CCX832 or its two designated back-up compounds.

 

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We expect our research and development expenses to increase as we advance our development programs further and increase the number and size of our clinical trials. The process of conducting preclinical studies and clinical trials necessary to obtain regulatory approval is costly and time consuming. We or our partners may never succeed in achieving marketing approval for any of our drug candidates. The probability of success for each drug candidate may be affected by numerous factors, including preclinical data, clinical data, competition, manufacturing capability and commercial viability. For the remaining product option covered under our strategic alliance with GSK, for which we receive milestone payments, we are responsible for development through clinical proof-of-concept, after which time GSK has an option to an exclusive license on a compound by compound basis. Our strategy includes entering into additional partnerships with third parties for the development and commercialization of some of our independent drug candidates that are not subject to our alliance with GSK.

Most of our product development programs are at an early-to-mid-stage; therefore the successful development of our drug candidates is highly uncertain and may not result in approved products. Completion dates and completion costs can vary significantly for each drug candidate and are difficult to predict for each product. Given the uncertainty associated with clinical trial enrollments and the risks inherent in the development process, we are unable to determine the duration and completion costs of the current or future clinical trials of our drug candidates or if, or to what extent, we will generate revenues from the commercialization and sale of any of our drug candidates. We anticipate we will make determinations as to which programs to pursue and how much funding to direct to each program on an ongoing basis in response to the scientific and clinical success of each drug candidate, as well as ongoing assessment as to each drug candidate’s commercial potential. We will need to raise additional capital or may seek additional strategic alliances in the future in order to complete the development and commercialization of our drug candidates, including CCX140, our lead independent drug candidate.

General and administrative expenses

Total general and administrative expenses were as follows (in thousands):

 

     Three Months Ended
September 30,
     Nine Months Ended
September 30,
 
     2012     2011      2012     2011  

General and administrative expenses

   $ 2,619      $ 1,772       $ 7,654      $ 5,721   

Dollar increase

     847           1,933     

Percentage increase

     48        34  

General and administrative expenses consist primarily of salaries and related benefits, including stock-based compensation and travel expenses, in executive, finance, business and corporate development and other administrative functions. Other general and administrative expenses include allocated facility-related costs not otherwise included in research and development expenses, legal costs of pursuing patent protection of our intellectual property, and professional fees for accounting, tax, and legal services.

The increases from 2011 to 2012 for both the three and nine month periods were primarily due to increased stock based compensation expense for 2012 stock option grants in addition to higher professional service fees relating to fulfilling our reporting obligations as a public company. We expect that general and administrative expenses will increase in the future as we expand our operating activities and incur additional costs associated with being a public company. These public company related increases will likely include legal fees, accounting fees, directors’ and officers’ liability insurance premiums and investor relations related fees.

Interest income (expense)

Interest income (expense), primarily consists of interest income earned on our marketable securities and interest expense incurred on our equipment financing obligations and convertible note. Total interest income (expense), net, as compared to prior years was as follows (in thousands):

 

     Three Months Ended
September 30,
    Nine Months Ended
September 30,
 
     2012     2011     2012     2011  

Interest income

   $ 141      $ 95      $ 411      $ 319   

Interest expense

     (20     (117     (776     (170

Other Income

     —          16        —          16   
  

 

 

   

 

 

   

 

 

   

 

 

 

Total interest income (expense) and other income, net

   $ 121      $ (6   $ (365   $ 165   
  

 

 

   

 

 

   

 

 

   

 

 

 

Dollar increase (decrease)

   $ 127        $ (530  

Percentage increase (decrease)

     2,117       (321 )%   

 

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Interest expense for the three months ended September 30, 2012 was primarily related to our interest expense due on our equipment lines of credit. Interest expense increased from 2011 to 2012 for the nine month period primarily due to the change in fair value of the convertible note we issued to Techne in September 2011 which was automatically converted into common stock as a result of our IPO in February 2012. In addition, interest income increased for both the three and nine month periods ended September 30, 2012 due to increased cash and investment balances following our IPO in February 2012.

Liquidity and Capital Resources

As of September 30, 2012, we had approximately $128.2 million in cash, cash equivalents and investments. The following table shows a summary of our cash flows for the nine months ended September 30, 2012 and 2011 (in thousands).

 

    

Nine Months Ended

September 30,

 
     2012     2011  

Cash provided by (used in)

    

Operating activities

   $ (24,736   $ (12,904

Investing activities

     (59,230 )     (3,295 )

Financing activities

     56,926        11,484   

Operating activities. Net cash used in operating activities was $24.7 million for the nine months ended September 30, 2012, compared to net cash used of $12.9 million for the same period in 2011. This change was primarily due to receipt of a $10.0 million milestone payment from GSK, earned in 2010 and received in 2011. No such payments were received in 2012. The net cash used in operating activities of $24.7 million for the nine months ended September 30, 2012 was primarily attributed to our net loss from operations, offset by changes in asset accounts following our IPO and non-cash charges for stock-based compensation in addition to the interest expense relating to the convertible note issued to Techne.

Investing activities. Net cash used in or provided by investing activities for periods presented primarily relate to the purchase, sale and maturity of investments used to fund the day-to-day needs of our business. Following our February 2012 IPO, we invested the majority of our net proceeds received in short and long term investments. We finance property and equipment purchases through equipment financing facilities. Proceeds from collaboration agreements and common stock issuances are used for general working capital purposes, such as research and development activities and other general corporate purposes.

Financing activities. Net cash provided by financing activities was $56.9 million for the nine months ended September 30, 2012, compared to $11.5 million for the same period in 2011. This increase was primarily due to $57.0 million in net proceeds from the issuance of a common stock as a result of our IPO and concurrent private placements in February 2012.

We believe that our existing cash, cash equivalents and investments as of September 30, 2012 will be sufficient to meet our anticipated cash requirements for at least the next 12 months. However, our forecast of the period of time through which our financial resources will be adequate to support our operations is a forward-looking statement that involves risks and uncertainties, and actual results could vary materially.

Our future capital requirements are difficult to forecast and will depend on many factors, including:

 

   

the achievement of milestones under our agreement with GSK;

 

   

the terms and timing of any other collaborative, licensing and other arrangements that we may establish;

 

   

the initiation, progress, timing and completion of preclinical studies and clinical trials for our drug candidates and potential drug candidates;

 

   

the number and characteristics of drug candidates that we pursue;

 

   

the progress, costs and results of our clinical trials;

 

   

the outcome, timing and cost of regulatory approvals;

 

   

delays that may be caused by changing regulatory approvals;

 

   

the cost and timing of hiring new employees to support continued growth;

 

   

the costs involved in filing and prosecuting patent applications and enforcing and defending patent claims;

 

   

the cost and timing of procuring clinical and commercial supplies of our drug candidates;

 

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the cost and timing of establishing sales, marketing and distribution capabilities; and

 

   

the extent to which we acquire or invest in businesses, products or technologies.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

Our market risks at September 30, 2012 have not changed significantly from those discussed in “Item 7A. Quantitative and Qualitative Disclosures About Market Risk” of our Annual Report on Form 10-K for the fiscal year ended December 31, 2011, filed with the SEC on March 30, 2012.

Item 4. Controls and Procedures

Conclusions Regarding the Effectiveness of Disclosure Controls and Procedures

As of September 30, 2012, management, with the participation of our Disclosure Committee, performed an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-15(e) of the Exchange Act. Our disclosure controls and procedures are designed to ensure that information required to be disclosed in the reports we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms, and that such information is accumulated and communicated to our management, including the Chief Executive Officer and the Chief Financial Officer, to allow timely decisions regarding required disclosures.

Any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objective. Based on this evaluation, our Chief Executive Officer and Chief Financial Officer concluded that, as of September 30, 2012, the design and operation of our disclosure controls and procedures were effective.

Changes in Internal Control Over Financial Reporting

There has been no change in our internal control over financial reporting during the nine month period ended September 30, 2012, that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

 

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PART II. OTHER INFORMATION

Item 1. Legal Proceedings

Not Applicable.

Item 1A. Risk Factors

There have been no material changes to the risk factors included in “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2011, filed with the SEC on March 30, 2012, other than as previously disclosed in our quarterly report on Form 10-Q for the quarter ended March 31, 2012, filed with the SEC on May 10, 2012.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

Unregistered Sales of Equity Securities

None.

Use of Proceeds

On February 8, 2012, our registration statement on Form S-1 (File No. 333-177332), which registered an aggregate amount of up to $73.6 million of our common stock, was declared effective by the SEC for our initial public offering, or IPO, pursuant to which we sold 5,175,000 shares of common stock at an IPO price of $10.00 per share, including the exercise of the underwriters’ over-allotment option. As a result of the IPO, we received gross proceeds of approximately $51.8 million, which resulted in net proceeds to us of approximately $45.0 million, after underwriting expenses of approximately $6.8 million (comprising $3.6 million in underwriting discounts and commissions and $3.2 million in other offering expenses). None of the expenses associated with the IPO were paid to directors, officers, persons owning ten percent or more of any class of equity securities, or to their associates, or to our affiliates. On February 13, 2012, following the sale of the 5,175,000 shares of common stock, the offering terminated.

We intend to use the net offering proceeds to advance our independent drug candidates through the clinic and for working capital and general corporate purposes. Through September 30, 2012, the net proceeds have been applied as follows: $9.3 million to further develop CCX140, $4.4 million to advance CCX168 and CCX662 and $4.3 million to fund other research and drug discovery programs.

Item 3. Defaults Upon Senior Securities

Not Applicable.

Item 4. Mine Safety Disclosures

Not Applicable.

Item 5. Other Information

Not Applicable.

Item 6. Exhibits

A list of exhibits is set forth on the Exhibit Index immediately following the signature page of this Quarterly Report on Form 10-Q, and is incorporated herein by reference.

 

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

 

  CHEMOCENTRYX, INC.
Date: November 13, 2012  

/s/ Thomas J. Schall, Ph.D.

 

Thomas J. Schall, Ph.D.

President and Chief Executive Officer

(Principal Executive Officer)

Date: November 13, 2012  

/s/ Susan M. Kanaya

 

Susan M. Kanaya

Senior Vice President, Finance,

Chief Financial Officer and Secretary

(Principal Financial and Accounting Officer)

 

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EXHIBIT INDEX

 

Exhibit
Number

 

Description

    3.1(1)   Amended and Restated Certificate of Incorporation.
    3.2(1)   Amended and Restated Bylaws.
  10.1   First Amendment to Standard Industrial/Commercial Multi-Tenant Lease, dated August 16, 2012, by and between Portola Land Company and the Registrant.
  31.1   Certification of Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
  31.2   Certification of Chief Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
  32.1   Certification of Chief Executive Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
  32.2   Certification of Chief Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
101*   The following information from the Registrant’s Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2012, formatted in XBRL (Extensible Business Reporting Language): (i) Consolidated Balance Sheets, (ii) Consolidated Statements of Operations, (iii) Consolidated Statements of Cash Flows, and (iv) the Notes to Consolidated Financial Statements, tagged as blocks of text.

 

(1) Filed with Amendment No. 3 to the Registrant’s Registration Statement on Form S-1 on January 23, 2012 (Registration No. 333-177332), and incorporated herein by reference.
* Users of this data are advised that pursuant to Rule 406T of Regulation S-T, this XBRL information is being furnished and not filed herewith for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and Sections 11 or 12 of the Securities Act of 1933, as amended, and is not to be incorporated by reference into any filing, or part of any registration statement or prospectus, of the Registrant, whether made before or after the date hereof, regardless of any general incorporation language in such filing.