UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

PURSUANT TO SECTION 13 OR 15(d) OF

THE SECURITIES EXCHANGE ACT OF 1934

DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): September 11, 2012

Fusion-io, Inc.

(Exact name of registrant as specified in its charter)

2855 E. Cottonwood Parkway, Suite 100

Salt Lake City, Utah 84121

(Address of principal executive offices) (Zip code)

(801) 424-5500

Registrant’s telephone number, including area code

Not Applicable

(Former name or former address if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

On September 11, 2012, Fusion-io, Inc. (the “Company”) entered into the Third Amendment to Amended and Restated Loan and Security Agreement with Silicon Valley Bank (the “Amendment”) which amends the Amended and Restated Loan and Security Agreement, dated as of September 13, 2010 (as amended, the “Loan Agreement”), by and between the Company and Silicon Valley Bank.

The Amendment extends the maturity date of the revolving line of credit under the Loan Agreement to December 31, 2012.

A copy of the Amendment is attached as Exhibit 10.1 to this current report on Form 8-K and is incorporated by reference herein. The foregoing description of the Amendment is qualified in its entirety by reference to the full text of such agreement.

On September 12, 2012, the Compensation Committee of the Board of Directors of the Company approved changes to base salaries for the Company’s named executive officers (as well as the Company’s executive officers expected to be identified as named executive officers in the Company’s proxy statement for its 2012 annual meeting), to be effective as of July 1, 2012, as follows:

Also on September 12, 2012, the Compensation Committee approved targets for short-term incentive award opportunities, which awards will be based on performance for the fiscal year ending June 30, 2013. These targets will be based on the following percentages of the respective officer’s base salary:

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Incentive compensation for these named executive officers has been established pursuant and subject to the terms of the Company’s Executive Incentive Compensation Plan, a copy of which was filed as an exhibit to the Company’s Registration Statement on Form S-1, as amended, filed on May 23, 2011.

Mr. Dawson’s short term incentive award target for fiscal year ending June 30, 2013 is 100% of his base salary and is structured as a sales-based commission program based on bookings goals and gross margin targets.

We expect to identify Mr. Boberg, our Executive Vice President, Strategic Business Development and General Manager of Caching Solutions, and Mr. Dawson, our Executive Vice President, Worldwide Sales, as named executive officers in the Company’s proxy statement for its 2012 annual meeting of stockholders. The Company is filing a copy of Mr. Boberg’s employment offer letter agreement as Exhibit 10.2 to this current report on Form 8-K. The Company has previously filed a copy of Mr. Dawson’s employment offer letter agreement as Exhibit 10.17 to the Company’s registration statement on Form S-1/A, as amended, filed on May 6, 2011. The employment agreements of Messrs. Boberg and Dawson, and all our named executive officers, are subject to the changes approved by the Compensation Committee described above.

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SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Dated: September 14, 2012

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