EXHIBIT 99.1

QCR Holdings, Inc. Announces Net Income of $2.1 Million for First Quarter of 2011

MOLINE, Ill., April 25, 2011 (GLOBE NEWSWIRE) -- QCR Holdings, Inc. (Nasdaq:QCRH) today announced net income attributable to QCR Holdings, Inc. ("net income") of $2.1 million for the quarter ended March 31, 2011, or diluted earnings per common share of $0.23 after preferred stock dividends of $1.0 million. By comparison, for the quarter ended December 31, 2010, the Company reported net income of $1.5 million, or diluted earnings per common share of $0.11 after preferred stock dividends of $1.0 million. For the first quarter of 2010, the Company reported net income of $1.3 million, or diluted earnings per common share of $0.06 after preferred stock dividends of $1.0 million.

Record Earnings for First Quarter of 2011

"We are pleased with our bottom-line results," stated Douglas M. Hultquist, President and Chief Executive Officer. "For continuing operations, we reported record earnings for the current quarter. Understanding the economic and regulatory backdrop, these results are a direct testament to our talented team of bankers and our unwavering commitment to our customer relationships."

The Company's net interest income for the current quarter totaled $12.2 million, relatively flat compared to the prior quarter, and a 5% decline from the first quarter of 2010.

Mr. Hultquist added, "Over the past year, maintaining net interest income has been a challenge as our overall liquidity position remains strong and we continue to operate in an environment with weak loan/lease demand and low-yielding alternative uses of funds. We continue to focus our efforts on managing the balance sheet to maximize net interest income while minimizing our liquidity risk, interest rate risk, and credit risk."

Continued Improvement in Nonperforming Assets

Nonperforming assets at March 31, 2011 were $44.2 million, down $5.8 million, or 12%, from $50.1 million at December 31, 2010. Nonperforming assets at the end of the quarter declined to 2.36% of total assets from 2.73% of total assets at December 31, 2010. The large majority of the Company's nonperforming assets consist of nonaccrual loans/leases and other real estate owned. A combination of improved performance ($4.9 million) and charge-offs ($881 thousand) contributed to the decrease. 

Provision for loan/lease losses totaled $1.1 million for the first quarter of 2011, a $2.0 million decrease over the prior quarter, and a decrease of $535 thousand from the first quarter of 2010. With provision for loan/lease losses of $1.1 million partially offset by net charge-offs of $702 thousand, the Company's allowance for loan/lease losses to total loans/leases increased from 1.74% at December 31, 2010 to 1.79% at March 31, 2011. 

"We are reporting continued improvement in the level of our nonperforming assets," stated Mr. Hultquist. "Specifically, nonperforming assets decreased $15.1 million, or 25%, over the past two quarters. This decline has translated immediately to a stronger income statement marked by a similar decline in our level of provision as well as legal and other expenses related to carrying elevated levels of nonperforming assets. Loan/lease expense for the current quarter is half of the amount incurred in the first quarter of 2010. We are pleased with these positive trends and remain committed to continued improvement in the quality of our loan/lease portfolio and all assets." 

Deposits Grew 7% in First Quarter of 2011

During the first quarter of 2011, the Company's total assets increased 2% from $1.84 billion at December 31, 2010 to $1.87 billion at March 31, 2011.  The Company grew its securities portfolio $66.7 million, or 16%, during the quarter. The growth was partially offset by a further decline in net loans/leases. The net increase in assets during the quarter was funded by strong and continued growth of the Company's deposit portfolio as balances grew $80.0 million, or 7%.

"We've remained persistent in our focus on originating quality loans and leases and continuing to meet the needs of our communities," stated Todd A. Gipple, Executive Vice President, Chief Operating Officer, and Chief Financial Officer. "We originated $87.6 million of new loans/leases to new and existing customers during the current quarter; however, this was outpaced by payments and maturities as we continued to experience weakened loan/lease demand in our markets."

Mr. Gipple added, "We are very pleased with the trends in our deposit portfolio. We've been successful in shifting our mix from brokered and other time deposits to noninterest-bearing and other interest-bearing nonmaturity deposits which has helped to drive down our cost of funds. Specifically, we've cut our brokered time deposit portfolio in half from $90.9 million at March 31, 2010 to $47.7 million at March 31, 2011. During that same time period, we've grown noninterest bearing deposits $72.6 million, or 35%. We continue to focus on growing our core deposit portfolios within our markets."

Mr. Gipple continued, "With the strong growth in our core deposits and the continued weak loan/lease demand over the past several quarters, our liquidity position has strengthened and we've carried excess liquidity on our balance sheet. The excess liquidity has compressed our net interest margin. During the current quarter, we invested a portion of the excess liquidity in additional government agency securities and government guaranteed residential mortgage-backed securities. The latter is a shift in mix for our securities portfolio in an effort to diversify and adapt to our changing balance sheet. As a result of the pledgability of these investments, we've effectively removed some of the negative arbitrage on our balance sheet without impacting our net liquidity position. We will continue to seek opportunities to increase our net interest income while balancing interest rate, liquidity, and credit risk."

Capital Levels Remain Very Strong

As of March 31, 2011, the Company and subsidiary banks continued to maintain capital at levels well above the minimum requirements administered by the federal regulatory agencies. "We remain committed to our long-term capital plan of preserving capital, increasing our tangible common equity, and redeeming the $38.2 million in Treasury Capital," stated Mr. Gipple. "Over the next few years, we intend to focus on improving our earnings and retaining those earnings to provide the excess capital needed to redeem the Treasury Capital without the need for a dilutive common equity raise. We believe that if we are successful in our efforts to return to more normalized levels of returns on assets, and if we are able to convert the Series E Preferred Stock to common equity in June 2013, we will be able to self-generate the equity needed to increase our tangible common equity and redeem Treasury Capital."

Successful Balance Sheet Restructuring of Company's Largest Subsidiary Bank

During the first quarter of 2011, the Company's largest subsidiary bank, Quad City Bank & Trust, successfully executed a restructuring of its balance sheet. Specifically, the bank utilized excess liquidity and prepaid $15.0 million of Federal Home Loan Bank ("FHLB") advances with a weighted average interest rate of 4.87%. The prepayment fees totaled $832 thousand and were more than offset by securities gains of $880 thousand. The proceeds from the sales of government agency securities were reinvested into government guaranteed residential mortgage-backed securities with yields that were comparable to the sold securities. Additionally, the bank modified $20.4 million of fixed rate FHLB advances into lower cost fixed rate advances with extended maturities. 

"We are very pleased with the results of this modest balance sheet restructuring at Quad City Bank & Trust," stated Mr. Gipple. "The impacts are significant and include a smaller balance sheet with reduced reliance on wholesale funding, stronger regulatory capital ratios, a significant reduction in interest expense, improved net interest margin, and minimal impact to stockholders' equity. In addition, the modification reduces interest expense and minimizes our exposure to rising rates. Altogether, the balance sheet restructuring efficiently achieved a number of critical goals for us."

Financial highlights for the Company's primary subsidiaries were as follows: 

• Quad City Bank & Trust, the Company's first subsidiary bank which opened in 1994, had total consolidated assets of $1.05 billion at March 31, 2011, which was an increase of $19.5 million, or 2%, from December 31, 2010. The bank's net loans/leases experienced a 1% decline due to continued weak loan/lease demand. During the quarter, the bank's securities portfolio grew $26.5 million, or 10%, to $295.9 million. The net growth was funded by continued expansion of the bank's deposit portfolio as total deposits grew $59.5 million, or 10%, during the first quarter. Specifically, the bank continues to have success growing its correspondent banking business as non-interest bearing correspondent deposits grew $35.7 million, or 44%, to $116.5 million. Partially offsetting the deposits growth, the bank reduced its borrowings position with the prepayment of $15.0 million of FHLB advances, and the maturity of another $7.0 million of FHLB advances. Quad City Bank & Trust realized net income of $1.9 million for the quarter ended March 31, 2011. By comparison, the bank realized net income of $1.4 million for the same period of 2010. 
• Cedar Rapids Bank & Trust, which opened in 2001, had total assets of $558.0 million at March 31, 2011, which was a 2% increase from December 31, 2010. With continued weak loan demand, Cedar Rapids Bank & Trust's loan portfolio declined $16.0 million, or 4%, to $343.7 million. Offsetting this decline, the bank grew its securities portfolio $44.3 million, or 40%, as it invested some of its excess liquidity.  The net growth was funded by deposits as total deposits grew $24.2 million, or 8%. Partially offsetting the deposits growth, the bank's borrowing position declined $13.8 million, or 8%. The bank realized net income of $1.3 million for the quarter ended March 31, 2011, which is a significant increase over the $792 thousand of net income for the same period of 2010.  
• Rockford Bank & Trust had total assets of $272.3 million at March 31, 2011, which was flat from December 31, 2010. During the first quarter, the bank grew loans $3.9 million, or 2%.  With deposits and borrowings flat during the quarter, the loan growth was funded by cashflow from called and matured securities. The bank continued its trend of profitability with net income of $231 thousand for the quarter ended March 31, 2011. By comparison, the bank reported net income of $281 thousand for the first quarter of 2010. 

QCR Holdings, Inc., headquartered in Moline, Illinois, is a relationship-driven, multi-bank holding company, which serves the Quad City, Cedar Rapids, and Rockford communities through its wholly owned subsidiary banks. Quad City Bank and Trust Company, which is based in Bettendorf, Iowa, and commenced operations in 1994, Cedar Rapids Bank and Trust Company, which is based in Cedar Rapids, Iowa, and commenced operations in 2001, and Rockford Bank and Trust Company, which is based in Rockford, Illinois, and commenced operations in 2005, provide full-service commercial and consumer banking and trust and asset management services. Quad City Bank and Trust Company also engages in commercial leasing through its 80% owned subsidiary, m2 Lease Funds, LLC, based in Milwaukee, Wisconsin.

Special Note Concerning Forward-Looking Statements. This document contains, and future oral and written statements of the Company and its management may contain, forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 with respect to the financial condition, results of operations, plans, objectives, future performance and business of the Company. Forward-looking statements, which may be based upon beliefs, expectations and assumptions of the Company's management and on information currently available to management, are generally identifiable by the use of words such as "believe," "expect," "anticipate," "predict," "suggest," "appear," "plan," "intend," "estimate," "annualize," "may," "will," "would," "could," "should" or other similar expressions. Additionally, all statements in this document, including forward-looking statements, speak only as of the date they are made, and the Company undertakes no obligation to update any statement in light of new information or future events.               

A number of factors, many of which are beyond the ability of the Company to control or predict, could cause actual results to differ materially from those in its forward-looking statements. These factors include, among others, the following: (i) the strength of the local and national economy; (ii) the economic impact of any future terrorist threats and attacks, and the response of the United States to any such threats and attacks; (iii) changes in state and federal laws, regulations and governmental policies concerning the Company's general business, including the recently enacted Dodd-Frank Wall Street Reform and Consumer Protection Act and the regulations to be issued thereunder; (iv) changes in interest rates and prepayment rates of the Company's assets; (v) increased competition in the financial services sector and the inability to attract new customers; (vi) changes in technology and the ability to develop and maintain secure and reliable electronic systems; (vii) the loss of key executives or employees; (viii) changes in consumer spending; (ix)  unexpected outcomes of existing or new litigation involving the Company; and (x) changes in accounting policies and practices. These risks and uncertainties should be considered in evaluating forward-looking statements and undue reliance should not be placed on such statements. Additional information concerning the Company and its business, including additional factors that could materially affect the Company's financial results, is included in the Company's filings with the Securities and Exchange Commission.

CONTACT: Todd A. Gipple
         Executive Vice President
         Chief Operating Officer
         Chief Financial Officer
         (309) 743-7745