UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K/A

AMENDMENT NO. 1 TO

CURRENT REPORT

Pursuant to Section 13 or 15(d) of The

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): January 25, 2011

TOWER BANCORP, INC.

(Exact name of registrant as specified in its charter)

Pennsylvania

(State or other jurisdiction of incorporation)

Registrant’s telephone number, including area code – (717) 231-2700

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

EXPLANATORY NOTE: This Amendment No. 1 to Current Report on Form 8-K/A (the “Amendment”) amends and restates in its entirety the discussion under the heading “Discretionary Cash Bonus Awards” appearing under Item 5.02 of the Current Report on Form 8-K filed by Tower Bancorp, Inc. (“Tower”) on January 27, 2011 (the “Initial Filing”). This Amendment is being filed in order to correctly report the amounts of the discretionary cash bonus awards payable to certain named executive officers of Tower, which were misreported in the Initial Filing due to a calculation error. As a result of the miscalculation, Tower underreported the aggregate amount of discretionary cash bonuses payable to named executive officers by $59,153, including a discretionary cash bonus to a named executive officer not included in the Initial Filing. Except as set forth in this Amendment, the disclosure contained in the Initial Filing remains unchanged.

Discretionary Cash Bonus Awards

On January 25, 2011, the Board of Directors of Tower awarded a discretionary cash bonus to Andrew Samuel, Chief Executive Officer, payable in February 2011, in connection with work completed in 2010. The Board’s decision to award a discretionary cash bonus, which is in addition to any amounts payable under Tower’s 2010 CEO Incentive Plan, was based upon the performance of Tower relative to its peers, key corporate accomplishments and other factors and achievements that the Board did not believe were adequately accounted for in the 2010 CEO Incentive Plan, including, but not limited to, the following:

Also on January 25, 2011, the Employee Development Committee of the Board of Directors of Tower awarded discretionary cash bonuses to certain other named executive officers, payable in February 2011, in connection with work completed in 2010. As with the above award to Mr. Samuel, the discretionary cash bonuses to certain named executive officers are in addition to any amounts payable under Tower’s 2010 Executive Incentive Plan and relate

to certain accomplishments and factors described above which the Employee Development Committee did not believe were adequately accounted for in the 2010 Executive Incentive Plan.

The discretionary cash bonuses awarded on January 25, 2011 are as follows.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.