Exhibit 99.1

FOR IMMEDIATE RELEASE		NEWS RELEASE

Tekelec Announces 2010 Operating Results

	•		2010 Revenues of $424.0 million;
	•		2010 Orders of $388.3 million;
	•		2010 GAAP Gross Margin of 60%, and non-GAAP Gross Margin of 65% (as reconciled below);
	•		2010 GAAP Operating Margin of 5%, and non-GAAP Operating Margin of 15% (as reconciled below);
	•		2010 GAAP Diluted EPS of $0.22 per share, and non-GAAP Diluted EPS of $0.64 per share (as reconciled below);

MORRISVILLE, N.C. — February 10, 2011 — Tekelec (NASDAQ: TKLC), the broadband data management company, today announced earnings for the fourth quarter and full year 2010.

Revenue for the fourth quarter of 2010 was $90.2 million, down 27% compared to $123.5 million for the fourth quarter of 2009. The Company’s orders were $178.4 million for the quarter, up 10% from the fourth quarter of 2009. Fourth quarter orders were the second highest in the Company’s history. Order input was up primarily due to a 16% year over year increase in SS7 and Sigtran orders for Eagle 5 with most of the growth occurring within North America. Included in the fourth quarter of 2010 is a $26 million dollar order from a North American customer for its 2011 Eagle 5 needs that we do not expect to repeat. As of December 31, 2010, backlog was $338.8 million compared to $253.6 million as of September 30, 2010 and $373.6 million as of December 31, 2009.

GAAP gross margins for the fourth quarter of 2010 were 54%, compared to 67% in the fourth quarter of 2009. Non-GAAP gross margins for the fourth quarter of 2010 were 61%, compared to 69% for the fourth quarter of 2009. Please refer to the attached reconciliations of the non-GAAP financial measures referred to in this release to the most directly comparable GAAP measures.

On a GAAP basis, the Company reported a net loss for the fourth quarter of 2010 of $8.0 million, or ($0.12) per share, compared to earnings in the fourth quarter of 2009 of $15.9 million, or $0.23 per diluted share. GAAP operating margins were a negative 15% for the fourth quarter of 2010 down from 18% for the fourth quarter of 2009.

On a non-GAAP basis, the Company reported a net loss for the fourth quarter of 2010 of $1.2 million, or ($0.02) per share, compared to net income of $19.4 million, or $0.28 per diluted share, for the fourth quarter of 2009. Non-GAAP operating margins for the fourth quarter of 2010 were a negative 2%, compared to 25% for the fourth quarter of 2009.

2010 Results

Revenue for 2010 was $424.0 million, down 10% compared to $469.3 million in 2009. The Company’s orders were $388.3 million, down 10% compared to $429.8 million in 2009. Growth in 2010 revenues and orders for next gen solutions were not able to offset the double digit declines in Eagle 5 revenues and orders.

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On a GAAP basis, the Company reported 2010 net income of $15.0 million, or $0.22 per diluted share, compared to $47.4 million, or $0.70 per diluted share in 2009. GAAP operating margins were 5% and 17% for 2010 and 2009, respectively.

On a non-GAAP basis, net income for 2010 was $44.3 million, or $0.64 per diluted share, compared to $70.4 million, or $1.04 per diluted share, for 2009. Non-GAAP operating margins for 2010 were 15% compared to 23% in 2009.

2010 Business Highlights

	•		Orders for next gen solutions increased 20% from 2009 levels to $106 million for 2010 on the strength of orders for policy and subscriber data management solutions.
	•		Next gen solution revenues increased 28% for the year compared to 2009 on the strength of revenues from our policy and subscriber data management solutions, consistent with the orders increase.
	•		Continued to expand our customer base by adding 28 new customers in 2010, including 16 that purchased next gen solutions.
	•		Increased the number of policy customers to 44 customers in 27 countries; 32 of these customers are tier one.
	•		Added 7 new subscriber data management customers since the acquisition of Blueslice — including 3 tier one customers who serve 190 million subscribers.
	•		Orders for policy and subscriber data management solutions were approximately $40 million for 2010, doubling our initial expectations at the time of the acquisitions of Camiant and Blueslice.
	•		Ended the year with a strong balance sheet with over $220 million dollars in cash and no debt.

Balance Sheet and Liquidity

As of December 31, 2010, the Company’s consolidated cash and cash equivalents totaled $220.9 million compared to cash and cash equivalents of $222.7 million at September 30, 2010. Cash flows from operations in 2010 were $22.6 million, compared to $55.1 million in 2009. Working capital at December 31, 2010 decreased to $286.9 million from $297.1 million at September 30, 2010.

2011 Full Year Guidance

We believe that full year 2011 revenues will range between $360 million and $400 million and non-GAAP gross margins will be in the low sixty percent range. Finally, we believe that our non-GAAP EPS range will be between $0.20 and $0.30 per diluted share and we expect the range for GAAP EPS will be between a loss of $0.15 and a loss of $0.25 per diluted share.

		2011
		Guidance
Revenues		$	360M - $400M
Non-GAAP Gross Margin*		low 60’s
Non-GAAP Diluted EPS **			$0.20 - $0.30
GAAP Diluted EPS			($0.25) - ($0.15	)

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“Live” Webcast and Replay

Tekelec will host a live webcast of its conference call on Thursday, February 10, 2011, at 8:00 a.m. EST to discuss 2010 results and certain forward-looking information concerning management’s outlook for the business. To access the webcast, visit Tekelec’s web site located at www.tekelec.com, enter the Investor Relations section and click on the webcast icon. A webcast replay will be available at approximately 11:00 a.m. EST on Thursday, February 10, 2011, and for 90 days thereafter. The Company also plans to provide on its web site immediately prior to the commencement of the call certain GAAP and non-GAAP information (including GAAP to non-GAAP reconciliations) and other financial information for the quarterly and full year periods.

Telephone Replay

A telephone replay of the call will also be available for one week after the live webcast by calling either (800) 642-1687 or (706) 645-9291, and entering the conference ID #39097158.

Non-GAAP Information

Certain non-GAAP financial measures are included in this press release. In the calculation of these measures, Tekelec generally excludes certain items such as amortization of acquired intangibles, restructuring and other charges, non-cash stock-based compensation charges, and unusual, non-recurring gains and charges. Tekelec believes that excluding such items provides investors and management with a representation of the Company’s core operating performance and with information useful in assessing its prospects for the future and underlying trends in Tekelec’s operating expenditures and continuing operations. Management uses such non-GAAP measures to (i) evaluate financial results, (ii) manage the Company’s operations, and (iii) establish operational goals. Further, non-GAAP measures are utilized by the Company’s management and board of directors to assist in determining incentive compensation and evaluating key trends within the business. In addition, since the Company has historically reported non-GAAP measures to the investment community, the Company believes the inclusion of this information provides consistency in our financial reporting. The release and the attachments to this release provide a reconciliation of each of the non-GAAP measures referred to in this release to the most directly comparable GAAP measure. The non-GAAP financial measures are not meant to be considered a substitute for the corresponding GAAP financial measures.

Forward-Looking Statements

Certain statements made in this press release, including 2011 Guidance, are forward-looking, reflect the Company’s current intent, belief or expectations and involve certain risks and uncertainties. The Company’s actual future performance may differ materially from such expectations as a result of important risk factors, which include, in addition to those identified in the Company’s 2009 Form 10-K, 2010 First, Second, and Third Quarter Forms 10-Q and its other filings with the Securities and Exchange Commission, the effects on our revenue performance of our year-over-year decline in orders in 2010 and the increasing portion of our orders that are for newer products with longer order-to-revenue conversion cycles; our increasing dependence on selling next generation products with which we have less experience forecasting and for which the markets are less mature and more subject to demand and technology changes; the difficulty we may have in transitioning from a hardware-centric to a software-centric business; the uncertainty associated with the resignation of our former CEO and the interim status of our current CEO; any adverse outcome from or effects of the securities litigations we currently have filed against us; the current or further detrimental changes in general economic, social, or political conditions in the countries in which we operate including the impact of credit availability and other economic factors on overall capital spending by our customers and resulting pressure on us to lower our prices; the rate and size of decline in demand for our older SS7-based products from which we still derive a substantial portion of our revenues; our ability to compete with other manufacturers that have lower cost bases than ours, are partially supported by foreign governments, and/or employ unfair trade practices; risks related to our international sales, markets and operations, including among others, import regulations, limited intellectual property protection, including protection of our software source code, increased costs and potential liabilities related to compliance with current and future security provisions in customer contracts and regulations, and security, access, and other regulatory requirements imposed by governments, including in particular the government of India; exposure to increased bad debt expense and product and service disputes as a result of general economic conditions; the timeliness and functional competitiveness of our product releases, the timing and size of any increase in demand for our performance management, SIP, Diameter, policy and subscriber database products; the risk of infringing on, and litigating with others regarding their, intellectual property rights; the timing of our recognition of

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revenues; the extent to which any customer outsourcing to our competitors or supplier consolidation increases the influence of competitors on our customers’ purchases; our ability to protect intellectual property rights; our ability to maintain OEM, partner, reseller, and vendor support and supply relationships; and changes in the market price of the Company’s common stock. The Company undertakes no obligation to publicly update any forward-looking statements whether as a result of new information, future events or otherwise.

About Tekelec

Tekelec enables billions of people and devices to talk, text, and access the Web. Our portfolio delivers a unique layer of intelligence allowing service providers to both manage and monetize the exponential growth in data traffic and applications. Tekelec has more than 25 offices around the world serving customers in more than 100 countries. For more information, please visit www.tekelec.com.

Contact:

Kyle Macemore | Vice President Finance and Investor Relations
(o) +1.919.380.6148 | kyle.macemore@tekelec.com

5200 Paramount Parkway, Morrisville, N.C., USA 27560 TEL +1.919.460.5500 FAX +1.919.460.0877

TEKELEC
UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

		Three Months Ended December 31,								Years Ended December 31,
		2010				2009				2010				2009
		(Thousands, except per share data)
Revenues		$	90,160			$	123,506			$	423,963			$	469,261
Cost of sales:
Cost of goods sold			35,609				38,640				151,572				152,417
Amortization of intangible assets			6,126				1,605				19,220				6,204
Total cost of sales			41,735				40,245				170,792				158,621
Gross profit			48,425				83,261				253,171				310,640
Operating expenses:
Research and development			23,681				24,734				92,347				100,337
Sales and marketing			22,588				17,070				78,446				68,644
General and administrative			13,486				15,718				52,662				56,006
Amortization of intangible assets			1,768				261				4,632				1,221
Acquisition-related expenses			103				—				2,994				—
Restructuring and other			—				2,984				—				2,984
Total operating expenses			61,626				60,767				231,081				229,192
Income (loss) from operations			(13,201	)			22,494				22,090				81,448
Other income (expense), net			(384	)			(1,468	)			(3,316	)			(14,755	)
Income (loss) from operations before provision for (benefit from) income taxes			(13,585	)			21,026				18,774				66,693
Provision for (benefit from) income taxes			(5,588	)			5,143				3,765				19,291
Net income (loss)		$	(7,997	)		$	15,883			$	15,009			$	47,402
Earnings (loss) per share:
Basic		$	(0.12	)		$	0.24			$	0.22			$	0.71
Diluted			(0.12	)			0.23				0.22				0.70
Weighted average number of shares outstanding:
Basic			68,599				67,355				68,284				66,900
Diluted			68,599				68,208				68,905				67,651

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TEKELEC
UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS

		December 31,
		2010				2009
		(Thousands, except share data)
ASSETS
Current assets:
Cash and cash equivalents		$	220,938			$	277,259
Trading securities, at fair value			—				81,788
Put right, at fair value			—				11,069
Accounts receivable, net			165,019				157,369
Inventories			28,221				23,353
Income taxes receivable			3,098				1,617
Deferred income taxes, current			19,906				66,758
Deferred costs and prepaid commissions			43,652				56,645
Prepaid expenses			8,527				7,007
Other current assets			3,687				1,943
Total current assets			493,048				684,808
Property and equipment, net			37,169				35,267
Deferred income taxes, net, noncurrent			72,854				39,153
Other assets			1,507				1,661
Goodwill			135,564				42,102
Intangible assets, net			92,245				31,017
Total assets		$	832,387			$	834,008
LIABILITIES AND SHAREHOLDERS’ EQUITY
Current liabilities:
Accounts payable		$	17,823			$	28,114
Accrued expenses			20,344				25,372
Accrued compensation and related expenses			22,680				40,980
Current portion of deferred revenues			145,291				149,065
Total current liabilities			206,138				243,531
Deferred income taxes, noncurrent			7,430				5,477
Long-term portion of deferred revenues			6,812				5,590
Other long-term liabilities			5,422				4,863
Total liabilities			225,802				259,461
Commitments and Contingencies
Shareholders’ equity:
Common stock, without par value, 200,000,000 shares authorized; 68,617,232 and 67,382,600 shares issued and outstanding, respectively			351,309				330,909
Retained earnings			256,829				241,820
Accumulated other comprehensive income			(1,553	)			1,818
Total shareholders’ equity			606,585				574,547
Total liabilities and shareholders’ equity		$	832,387			$	834,008

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TEKELEC
UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

		Years Ended December 31,
		2010				2009
		(Thousands)
Cash flows from operating activities:
Net income		$	15,009			$	47,402
Adjustments to reconcile net income to net cash provided by operating activities:
Impairment of investment in privately-held company			—				13,587
Gain (loss) on investments carried at fair value, net			(118	)			(1,846	)
Provision for doubtful accounts and returns			2,710				2,228
Provision for (reduction of) warranty			(1,639	)			3,875
Inventory write downs			4,528				6,165
Loss on disposals of fixed assets			121				147
Depreciation			16,453				18,105
Amortization of intangibles			23,852				7,425
Amortization of deferred financing costs and other			698				748
Deferred income taxes			1,252				8,035
Stock-based compensation			12,525				13,537
Excess tax benefits from stock-based compensation			(873	)			(840	)
Changes in operating assets and liabilities (net of acquisitions and dispositions):
Accounts receivable			(6,277	)			13,723
Inventories			(8,979	)			(5,752	)
Deferred costs			14,175				819
Prepaid expenses			(1,728	)			1,424
Other current assets			912				(246	)
Accounts payable			(16,486	)			2,545
Accrued expenses			(3,926	)			(9,498	)
Accrued compensation and related expenses			(19,291	)			(249	)
Deferred revenues			(8,801	)			(56,561	)
Income taxes receivable			(2,049	)			(1,796	)
Income taxes payable			541				(7,883	)
Total adjustments			7,600				7,692
Net cash provided by operating activities — continuing operations			22,609				55,094
Net cash used in operating activities — discontinued operations			—				(184	)
Net cash provided by operating activities			22,609				54,910
Cash flows from investing activities:
Proceeds from sales and maturities of investments			92,975				23,635
Purchase of acquired business, net of cash acquired			(161,953	)			—
Purchases of property and equipment			(17,659	)			(18,720	)
Net cash provided by (used in) investing activities			(86,637	)			4,915
Cash flows from financing activities:
Proceeds from issuance of common stock			10,950				9,886
Cash used to net share settle equity awards			(3,075	)			(2,289	)
Excess tax benefits from stock-based compensation			873				840
Net cash provided by financing activities			8,748				8,437
Effect of exchange rate changes on cash			(1,041	)			(444	)
Net increase (decrease) in cash and cash equivalents			(56,321	)			67,818
Cash and cash equivalents at beginning of the year			277,259				209,441
Cash and cash equivalents at end of the year		$	220,938			$	277,259

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TEKELEC
RECONCILIATIONS OF SELECTED GAAP MEASURES TO NON-GAAP MEASURES
for the Three Months Ended December 31, 2010 and 2009

		2010								2009
		Amount				% of revenues				Amount				% of revenues
		(Thousands, except percentages)
Gross margins		$	48,425				54	%		$	83,261				67	%
Adjustments:
Amortization of intangible assets (1)			6,126				7	%			1,605				1	%
Stock-Based Compensation (2)			278				0	%			265				0	%
Acquisition related cash bonus(3)			53				0	%			—				0	%
Non-GAAP gross margins		$	54,882				61	%		$	85,131				69	%

		2010								2009
		Amount				% of revenues				Amount				% of revenues
		(Thousands, except percentages)
Operating margins		$	(13,201	)			-15	%		$	22,494				18	%
Adjustments:
Amortization of intangible assets(1)			7,894				9	%			1,866				2	%
Stock-Based Compensation (2)			2,611				3	%			3,262				3	%
Acquisition related cash bonus(3)			615				1	%			220				0	%
Acquisiton related expenses-other(4)			103				0	%			—				—
Restructuring and other(5)			—				—				2,984				2	%
Non-GAAP operating margin (loss)		$	(1,978	)			-2	%		$	30,826				25	%

		2010								2009
		Amount				per diluted share				Amount				per diluted share
		(Thousands, except per share data)
Net income (loss)		$	(7,997	)		$	(0.12	)		$	15,883			$	0.23
Adjustments:
Amortization of intangible assets(1)			7,894				0.12				1,866				0.03
Stock-Based Compensation (2)			2,611				0.04				3,262				0.05
Acquisition related cash bonus(3)			615				0.01				220				0.00
Acquisiton related expenses-other(4)			103				0.00				—				—
Restructuring and other(5)			—				—				2,984				0.04
Provision for (benefit from) income taxes (6)			(4,407	)			(0.06	)			(4,839	)			(0.07	)
Non-GAAP net income (loss)		$	(1,181	)		$	(0.02	)		$	19,376			$	0.28
Weighted average number of shares outstanding:
Basic							68,599								67,355
Diluted							68,599								68,208

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TEKELEC
RECONCILIATIONS OF SELECTED GAAP MEASURES TO NON-GAAP MEASURES
for the Years Ended December 31, 2010 and 2009

		2010								2009
						% of								% of
		Amount				revenues				Amount				revenues
		(Thousands, except percentages)
Gross margins		$	253,171				60	%		$	310,640				66	%
Adjustments:
Amortization of intangible assets(1)			19,220				5	%			6,204				1	%
Stock-Based Compensation (2)			1,326				0	%			1,050				0	%
Acquisition related cash bonus(3)			230				0	%			—				0	%
Non-GAAP gross margins		$	273,947				65	%		$	317,894				68	%

		2010								2009
						% of								% of
		Amount				revenues				Amount				revenues
		(Thousands, except percentages)
Operating margins		$	22,090				5	%		$	81,448				17	%
Adjustments:
Amortization of intangible assets(1)			23,852				6	%			7,425				2	%
Stock-Based Compensation (2)			12,525				3	%			13,537				3	%
Acquisition related cash bonus(3)			3,783				1	%			880				0	%
Acquisiton related expenses-other(4)			2,994				1	%			—				0	%
Restructuring and other(5)			—				0	%			2,984				1	%
Non-GAAP operating margins		$	65,244				15	%		$	106,274				23	%

		2010								2009
						Per								per
						diluted								diluted
		Amount				share				Amount				share
		(Thousands, except per share data)
Net income		$	15,009			$	0.22			$	47,402			$	0.70
Adjustments:
Amortization of intangible assets (1)			23,852				0.35				7,425				0.11
Stock-Based Compensation (2)			12,525				0.18				13,537				0.20
Acquisition related cash bonus(3)			3,783				0.05				880				0.01
Acquisiton related expenses-other(4)			2,994				0.04				—				—
Restructuring and other(5)			—				—				2,984				0.04
Impairment of investment in privately-held company(6)			—				—				12,917				0.19
Provision for (benefit from) income taxes (7)			(13,829	)			(0.20	)			(14,746	)			(0.22	)
Non-GAAP net income		$	44,334			$	0.64			$	70,399			$	1.04
Weighted average number of shares outstanding:
Basic							68,284								66,900
Diluted							68,905								67,651

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