Exhibit 10.1

April 13, 2010

Joe Slattery
19316 Cissel Manor Drive
Poolesville, Maryland 20837

     Re: Offer of Employment with TranS1 Inc.

Dear Joe:

     On behalf of TranS1 Inc., a Delaware corporation (the “Company”), I am pleased to invite you to join the Company as its Executive Vice President and Chief Financial Officer. The first day of your employment will be no later than Monday, April 19, 2010, or such other date as you and the Company mutually agree in writing (“Effective Date”).

     The terms of this offer of employment are as follows:

     1. At-Will Employment; Position and Duties.

          (a) At-Will Employment. You should be aware that your employment with the Company is for no specified period and constitutes “at-will” employment. As a result, either you or the Company may terminate your employment with the Company at any time and for any or no reason. We request that you give the Company at least thirty (30) days’ notice in the event of a resignation without Good Reason (as defined under Section 6 below).

          (b) Position and Duties. As of the Effective Date, you will serve as the Chief Financial Officer of the Company, reporting directly to me, the Company’s Chief Executive Officer. In this position, you will be expected to devote your full business time, attention and energies to the performance of your duties with the Company; provided, however, we acknowledge and consent to your being on and serving on two outside boards of directors, so long as such service does not impair your ability to serve in your new role with us.

          (c) Board of Directors. In connection with your commencement of employment with the Company you shall resign your positions on the Board of Directors and the Audit Committee of the Company. Options granted to you as a member of our Board of Directors will remain in effect and continue to vest in accordance with their original terms.

     2. Compensation. The Company will pay you a salary at the rate of $285,000.00 per year payable in accordance with the Company’s standard payroll policies, including compliance with applicable withholding (the “Base Salary”). Any increased or decreased Base Salary shall serve as the “Base Salary” for future employment under this offer letter. The first and last payment by the

Joe Slattery
April 13, 2010
Page 2

Company to you will be adjusted, if necessary, to reflect a commencement or termination date other than the first or last working day of a pay period.

     3. Stock Option.

          (a) Grant. Subject to approval by the Company’s Board of Directors, you will be granted an option pursuant to the Company’s 2005 Stock Plan (the “Plan”) to purchase 200,000 shares of the Company’s Common Stock at an exercise price equal to the fair market value per share of the Company’s Common Stock on the date the Board of Directors approves the option grant (the “Option Grant”). The Option Grant shall be subject to the terms and conditions of the Plan and the Company’s standard form of stock option agreement. The Option Grant shall be made in the form of an incentive stock option, to the maximum extent permitted by law, with the remainder of the grant made in the form of non-qualified stock options.

          (b) Vesting Schedule; Exercise Terms. One-fourth (1/4th) of the shares subject to the Option Grant will vest on the first anniversary of the Effective Date and an additional one thirty-sixth (1/36^th) of the remaining number of such shares will vest each month thereafter, subject to your continued employment with the Company on each such date. The Option Grant shall be exercisable up to the number of vested shares according to the vesting schedule set forth in the preceding sentence. The term of the option grant will be [10] years from date of grant.

          (c) Change of Control. In the event of a Change of Control, if you are not employed by the successor of our business as the Chief Financial Officerof the successor all then-unvested options under the Option Grant shall vest and become exercisable on the effective date of such Change of Control. If you are so employed as the Chief Financial Officer or such higher position as you should then hold with the Company of the successor’s business and the successor assumes or replaces your Options, then your Options will continue to vest as provided above. If you are so employed and your employment with the successor is terminated by the successor without Cause or by you for Good Reason within twelve months of the effective date of such Change of Control your Options shall vest and become exercisable.

     4. Bonus.

          Annual Bonus. You will be eligible to earn a target bonus of forty percent (40%) of your Base Salary, based upon the achievement of Company and individual goals that will be determined by the Company’s Board of Directors. The bonus, if any, will be determined and paid on an annual basis at the sole discretion of the Board of Directors, at the time and manner to be determined by the Board of Directors. You must be employed on the date that your bonus, if any, is to be paid in order to earn and be eligible to receive the bonus.

     5. Benefits.

          (a) Standard. During the term of your employment, you will be eligible to participate in the Company’s standard benefits covering Company employee executives at your level, as such may be in effect from time to time. Upon your employment, you will be granted four (4) weeks of paid vacation time.

Joe Slattery
April 13, 2010
Page 3

          (b) Relocation. In connection with your joining the Company we have agreed that you shall move your permanent residence to the Raleigh/Durham, North Carolina area. In connection with such move from your current principal residence in Maryland, the Company shall reimburse you for all relocation expenses incurred during the twelve (12) month period commencing on April 19, 2010, including (i) travel, lodging and ground transportation for at least two house hunting trips, each of which may be for up to three (3) days, (ii) packing and moving all household goods, not including items requiring special takedown or setup or special handling or transporting, (iii) $75,000 of insurance covering household goods during the move, (iv) transportation of household goods from your present residence in Maryland to your new home in Raleigh, North Carolina, (v) up to 30 days of storage of your household goods, (vi) reasonable temporary housing expense for up to sixty (60) days and one trip returning to your current residence for every three weeks of temporary residency, (vii) reimbursement for reasonable and customary realtor commissions and conventional closing costs for the sale and purchase of new homes of equivalent values, (viii) a $12,000 stipend for miscellaneous costs associated with moving into a new home, such as utility and telecommunication hookups, and (ix) tax “gross-up” payment for any incremental personal Federal and state tax liability associated with moving expenses reimbursed. Please remember that all expenses for relocation will require proper receipts and prior approval from the CEO to qualify for reimbursement. Should you resign your employment with the Company during the first twelve (12) months of your employment one hundred percent (100%) of your relocation costs paid to you or on your behalf will be refunded to the Company by you, unless such resignation is for Good Reason as defined below. In the event you resign your employment with the Company during the period from twelve (12) months to twenty-four (24) months after your commencement date you will reimburse to the Company fifty percent (50%) of the relocation expense paid to you or on your behalf unless you resign for Good Reason as defined below.

     6. Definitions.

          (a) Cause. For purposes of this offer letter, “Cause” shall mean: (1) your gross negligence in the performance of or failure to perform the duties and obligations of your position with the Company or under this offer letter (for reasons other than death or Disability), which gross negligence, if curable within the discretion of the Company’s Board of Directors, is not cured to the reasonable satisfaction of the Company’s Board of Directors within thirty (30) days after receipt of written notice from the Board of Directors of such failure; (ii) any act of personal dishonesty, fraud, embezzlement, misrepresentation, or any unlawful act committed by you that results in your substantial gain or personal enrichment at the expense of the Company; (iii) your violation of a federal or state law or regulation applicable to the Company’s business; (iv) your violation of or a plea of nolo contendere or guilty to, a felony under the laws of the United States or any state; or (v) your material breach of the terms of this offer letter or the Confidentiality Agreement.

          (b) Change of Control. For purposes of this offer letter, “Change of Control” shall mean the occurrence of any of the following events:

               (i) Any “person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the “beneficial owner” (as defined in Rule 13d-3 of the Exchange Act), directly or indirectly, of securities of the Company representing fifty percent (50%) or more of the total voting power represented by the Company’s then outstanding voting securities, except that any change in the beneficial ownership of the securities of the Company as a result of an equity financing

Joe Slattery
April 13, 2010
Page 4

of the Company that is approved by the Company’s Board of Directors, shall not be deemed to be a Change in Control; or

               (ii) The consummation of the sale or disposition by the Company of all or substantially all of the Company’s assets; or

               (iii) The consummation of a merger or consolidation of the Company with any other corporation, other than a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or its parent) at least fifty percent (50%) of the total voting power represented by the voting securities of the Company or such surviving entity or its parent outstanding immediately after such merger or consolidation.

          (c) Disability. For purposes of this offer letter, “Disability” shall mean that you, at the time notice is given have been unable to substantially perform your duties of your position with the Company or under this offer letter for not less than one-hundred and twenty (120) work days within a twelve (12) consecutive month period as a result of your incapacity due to a physical or mental condition and, if reasonable accommodation is required by law, after any reasonable accommodation.

          (d) Good Reason. For purposes of this offer letter and prior to a Change of Control, “Good Reason” shall mean, without your written consent: (i) there is a material reduction of the level of your compensation (excluding any bonuses) (except where there is a general reduction applicable to the management team generally); (ii) there is a material reduction in your overall responsibilities or authority, or scope of duties; or (iii) there is a material change in the geographic location at which you must perform your services; provided however, that in no instance will such a relocation to an office location fifty (50) miles or less from the Company’s current office location or a relocation that does not require you to move from your anticipated new home in Raleigh, North Carolina be deemed material for purposes of this offer letter. For purposes of this offer letter and after a Change of Control but prior to the expiration of the twelve months after the Change of Control, “Good Reason” shall mean, without your written consent: (i) there is a material reduction of the level of your compensation (excluding any bonuses) below the amount set forth in the first sentence of Section 2 above; (ii) you are not the Chief Financial Officer of the successor’s business; or (iii) there is a material change in the geographic location at which you must perform the your services after the Change of Control; provided however, that in no instance will such a relocation to an office location fifty (50) miles or less from the Company’s office location immediately preceding the Change of Control or a relocation that does not require you to move from your anticipated new home in Raleigh, North Carolina be deemed material for purposes of this offer letter.

     7. Immigration Laws. For purposes of federal immigration laws, you will be required to provide to the Company documentary evidence of your identity and eligibility for employment in the United States. Such documentation must be provided within three (3) business days of the effective date of your employment, or your employment relationship with the Company may be terminated. You understand and agree that any termination under this Section 10 for failure to properly provide the requested documentation shall be considered the same as a termination for Cause under this offer letter.

Joe Slattery
April 13, 2010
Page 5

     8. Employee Proprietary Information Agreement. As a condition of this offer of employment, you will be required to complete, sign and return the Company’s standard form of At-Will Employee Confidential and Proprietary Information Agreement (the “Confidentiality Agreement”). A copy of the Confidentiality Agreement is attached hereto as Exhibit A.

     9. General. This offer letter, the Confidentiality Agreement and the stock option agreement (as approved by the Board of Directors) covering the Option Grant, when signed by you, set forth the terms of your employment with the Company and supersede any and all prior representations and agreements, whether written or oral. In the event of a conflict between the terms and provisions of this offer letter and the Confidentiality Agreement and the stock option agreement, the terms and provisions of the Confidentiality Agreement and the stock option agreement will control. Any amendment of this offer letter or any waiver of a right under this offer letter must be in a writing signed by you and an officer of the Company or a member of the Company’s Board of Directors (other than yourself). North Carolina law will govern this offer letter.

     We look forward to you joining the Company. If the foregoing terms are agreeable, please indicate your acceptance by signing this offer letter and returning it to me, along with your completed and signed Confidentiality Agreement.

[Signature pages to follow]

AGREED TO AND ACCEPTED:
“Employee”
/s/ Joseph P. Slattery   Joseph P. Slattery

Signature Page to Employment Offer Letter

Exhibit A

Confidentiality Agreement