Exhibit 10.35

FIRST AMENDMENT TO LEASE AGREEMENT

THIS FIRST AMENDMENT TO LEASE AGREEMENT (“Amendment”) is entered into this the 24th day of July, 2008, between Hudson-Alpha Institute for Biotechnology, an Alabama non-profit corporation (“Landlord”), and Applied Genomics, Inc., a Delaware corporation, (“Tenant”).

R E C I T A L S:

A. Landlord and Tenant are parties to that certain Lease Agreement (the “Lease”) dated January 15, 2008, with respect to the Premises in the Building, as such terms are defined in the Lease. Any capitalized term used but not defined herein shall have the meaning ascribed to it in the Lease.

B. Since the execution of the Lease by Landlord and Tenant, the actual location of the Premises occupied by Tenant has changed, and Landlord and Tenant have agreed to amend to Lease to reflect the correct description of the Premises and the amount of square footage of the same.

A G R E E M E N T:

NOW, THEREFORE, for and in consideration of the recitals set forth above, and other good and valuable consideration, the receipt and sufficiency of which are acknowledged, Landlord and Tenant hereby agree as follows:

1. Substitution of Premises Exhibit to Lease. The Lease is hereby amended to delete Exhibit A to the Lease in its entirety and to substitute in lieu thereof Exhibit A attached hereto and incorporated herein by reference.

2. Amendment to Section 1.01 and Section 3.01 of the Lease. Section 1.01 and Section 3.01 of the Lease are hereby amended to reflect that the correct Usable Area of the leased premises in Suite 2200 is 5,756 square feet, and the correct Usable Area of basement storage is 0 square feet. As of date of this Amendment, the term “Premises” as used throughout the Lease shall be deemed to refer to the leased premises as described in this Amendment, including without limitation Exhibit A attached hereto.

3. Miscellaneous. Except as amended hereby, the Lease is unchanged, and by execution and delivery of this Amendment, Landlord and Tenant each do ratify and affirm the Lease, as amended hereby. This Amendment may be executed in one or more counterparts, all of which taken together shall constitute one original instrument.

IN WITNESS WHEREOF, Landlord and Tenant have caused this Amendment to be duly executed as a sealed instrument as of the day and year first above written.

FIRST AMENDMENT TO LEASE AGREEMENT

(Landlord’s signature page)

STATE OF ALABAMA			)
			:
MADISON COUNTY			)

I, the undersigned, a notary public in and for said county in said state, hereby certify that H. O’Neal Smitherman, whose name as Executive Vice President of Hudson-Alpha Institute for Biotechnology, an Alabama nonprofit corporation, is signed to the foregoing instrument, and who is known to me, acknowledged before me on this day that, being informed of the contents of said instrument, he, as such officer and with full authority, executed the same voluntarily for and as the act of said corporation.

Given under my hand and official seal this 24^th day of July, 2008.

My commission expires: September 25, 2011

[NOTARIAL SEAL]

FIRST AMENDMENT TO LEASE AGREEMENT

(Tenant’s signature page)

STATE OF ALABAMA			)
			:
MADISON COUNTY			)

I, the undersigned, a notary public in and for said county in said state, hereby certify that Robert S. Seitz, whose name as Chief Executive Officer of Applied Genomics, Inc., a Delaware corporation, is signed to the foregoing instrument, and who is known to me, acknowledged before me on this day that, being informed of the contents of said instrument, he, as such officer and with full authority, executed the same voluntarily for and as the act of said Applied Genomics, Inc.

Given under my hand and official seal this 24^th day of July, 2008.

My commission expires: September 25, 2011

[NOTARIAL SEAL]

EXHIBIT A

Premises Floor Plan

See attached.

Item		Room No.		Room Name		Usable SF				Associate
216		CL225		Closet			17			AGI
217		CL228		Closet			16			AGI
218		CL229		Closet			16			AGI
219		CL232		Closet			29			AGI
219		CL233		Closet			0			AGI		Corrected 7/16/08, included in CL232
220		CL234		Closet			15			AGI
290		2138		AGI Tissue Storage			462			AGI
296		2200		AGI Admin			178			AGI		Corrected 6/16/08
297		2201		AGI Executive			248			AGI
298		2203		AGI Executive			187			AGI
299		2204		AGI Arrayer Room			233			AGI
300		2205		AGI Executive			344			AGI
302		2207		AGI Main Lab			2,298			AGI
303		2208		AGI Scoring Room			124			AGI
304		2209		AGI Tissue Array Lab			1,427			AGI
305		2210		AGI Conference			124			AGI
306		2210A		AGI Pantry			38			AGI
												5,756