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EXHIBIT 32.1


               CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                 SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

         In connection with the Quarterly Report of Aethlon Medical, Inc. on
Form 10-Q for the fiscal quarter ended September 30, 2009 as filed with the
Securities and Exchange Commission on the date hereof, I, James A. Joyce, Chief
Executive Officer and Chief Accounting Officer of the Company, certify, pursuant
to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002, that:

         1. Based on my knowledge, the Quarterly Report fully complies with the
requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934,
as amended, and

         2. The information contained in such Quarterly Report on Form 10-Q
fairly presents, in all material respects, the financial condition and results
of operations of Aethlon Medical, Inc.

Date: November 16, 2009

By: /s/ James A. Joyce
    -----------------------
    James A. Joyce
    Chief Executive Officer and Chief Accounting Officer

A signed original of this written statement required by Section 906, or other
document authenticating, acknowledging, or otherwise adopting the signature that
appears in typed form within the electronic version of this written statement
required by Section 906, has been provided to Aethlon Medical, Inc. and will be
retained by Aethlon Medical, Inc. and furnished to the Securities and Exchange
Commission or its staff upon request.